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A systematic screening for measles, mumps, rubella (MMR) and varicella zoster virus (VZV) in HIV-positive adult immigrants in Spain was evaluated, and factors associated with MMR and VZV vaccines' indication were studied. Every HIV-positive immigrant was tested for VZV and MMR-IgG. MMR vaccine was indicated to patients with lymphocytes CD4+ >200 cells/mm³ and a negative measles-IgG, a negative mumps-IgG and/or a negative rubella-IgG. VZV vaccine was indicated to every VZV-IgG negative patient with CD4+ >400 cells/mm³. In total, 289 patients were screened; seroprevalence was 95.2%, 92.2%, 70.3% and 89.3% for VZV, measles, mumps and rubella IgG, respectively. Having a negative VZV-IgG was statistically associated with coming from sub-Saharan Africa (prevalence ratio [PR]: 6.52; 95% CI: 1.71-24.84; p=0.006), while having secondary education was a protective factor (PR: 0.25; 95% CI: 0.07-0.97; p=0.045). Fourteen patients (4.8%) had indication of VZV vaccine; vaccination was feasible in 21.4% of them at first visit. Eighty-one patients (29.7%) had indication of MMR vaccine, most of them due to mumps-IgG negative (53.1%) or rubella-IgG negative (24.7%). Age < 30 years at first visit was the only factor statistically associated with MMR vaccine indication (PR: 1.47; 95% CI: 1.02-2.11; p=0.04). According to CD4+ cell counts, vaccination was feasible in 71.6% of patients at first visit. In conclusion, more than a third of HIV-infected immigrant patients are susceptible to at least one easily preventable infectious disease. Especial attention should be given to immigrant women of childbearing age.

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Objectives. Vaccination against SARS-CoV-2 is essential to mitigate the personal, social and global impact of the coronavirus disease (COVID-19) as we move from a pandemic to an endemic phase. Vaccines are now required that offer broad, long-lasting immunological protection from infection in addition to protection from severe illness and hospitalisation. Here we present a review of the evidence base for a new COVID-19 vaccine, PHH-1V (Bimervax®; HIPRA HUMAN HEALTH S.L.U), and the results of an expert consensus. Materials and methods. The expert committee consisted of Spanish experts in medicine, family medicine, paediatrics, immunology, microbiology, nursing, and veterinary medicine. Consensus was achieved using a 4-phase process consisting of a face-to-face meeting during which the scientific evidence base was reviewed, an online questionnaire to elicit opinions on the value of PHH-1V, a second face-to-face update meeting to discuss the evolution of the epidemiological situation, vaccine programmes and the scientific evidence for PHH-1V and a final face-to-face meeting at which consensus was achieved. Results. The experts agreed that PHH-1V constitutes a valuable novel vaccine for the development of vaccination programmes aimed towards protecting the population from SARS-CoV-2 infection and disease. Consensus was based on evidence of broad-spectrum efficacy against established and emerging SARS-CoV-2 variants, a potent immunological response, and a good safety profile. The physicochemical properties of the PHH-1V formulation facilitate handling and storage appropriate for global uptake. Conclusions. The physicochemical properties, formulation, immunogenicity and low reactogenic profile of PHH-1V confirm the appropriateness of this new COVID-19 vaccine.

RESUMENEl objetivo de la presente investigación fue evaluar la variabilidad genética de una población de cerdo doméstico (Sus scrofa domestica) en Sampués, Sucre, Colombia, para determinar su situación genética. Se estudiaron 50 muestras de la población. Se utilizaron 20 microsatélites, cinco pertenecientes a la lista de los recomendados por la FAO/ISAG para estudios de biodiversidad porcina y los restantes representan la mayor parte del genoma porcino. Se pudo precisar que los microsatélites utilizados resultaron polimórficos, detectándose entre 3 (SW2019) y 14 (SW957) alelos, con un número medio de alelos de 6 y un total de 120. La heterocigosidad media esperada fue de 0.5465 y la heterocigosidad media observada fue de 0.5203. Los valores del contenido de información polimórfica (PIC) oscilaron entre 0.2823 y 0.7252 para los loci SW1041 y SW957, respectivamente. Los resultados muestran a la población de cerdos estudiada como un grupo con alto grado de diversidad genética.Palabras clave: marcadores microsatélites, Sus scrofa domestica, diversidad, equilibrio Hardy-Weinberg, Sampués ABSTRACTThe aim of this research was to evaluate the genetic variability of a population of domestic pigs (Sus scrofa domestica) in Sampués, Sucre, Colombia to determine their genetic status. Fifty samples were studied. Twenty microsatellites were used where five of them were from the list of those recommended by FAO/ISAG for studies of swine biodiversity and the remaining represent most of the pig genome. The microsatellites