Concomitant administration of chemotherapy and radiotherapy is currently recognized as the standard of treatment in locally advanced inoperable non-small cell lung cancer (NSCLC). Our study aimed to compare the efficacy and toxicities of three different chemotherapy regimens delivered concurrently with radiotherapy. We retrospectively reviewed the clinical records of patients who received the PE (cisplatin, 50 mg/m(2), on days 1, 8, 29, and 36 plus etoposide, 50 mg/m(2), on days 1 to 5 and 29 to 33), PD (docetaxel, 20 mg/m(2), on day 1 plus cisplatin, 20 mg/m(2), on day 1, every week), and PC (carboplatin, AUC 2 plus paclitaxel, 45 mg/m(2), on day 1, every week) regimens concurrently with radiotherapy. A total of 227 patients were evaluated in the study. Median follow-up time was 13 months (2-101). There were 27 females (11.9 %) and 200 males (88.1 %) with a median age of 61 (38-82) years. The PD group had higher rates of esophagitis, mucositis, and anemia (p < 0.05). The PC group had higher rates of neuropathy (p = 0.000). The progression-free survival (PFS) time was 10 months for patients in the PC group, 15 months for patients in the PD group, and 21 months for the PE group (p = 0.010). Patients in the PC group had a median overall survival time of 23 months, those in the PD group 27 months, and those in the PE group 36 months (p = 0.098). Combination of cisplatin-etoposide with radiotherapy led to a more favorable outcome compared with the other two regimens. It shows generally manageable toxicity profile and compliance to treatment is noticeable.

Introduction and Aims: Synthetic cannabinoid (SCs) use has been increasing in Turkey parallel to the rest of the world. It is more commonly named as bonzai, jamaica, k2 or spice and is used illegally for pleasure and hallucinogenic effects. Here we presented six patients who were followed up in Nephrology clinic with acute kidney injury (AKI) due to synthetic cannabinoid usage in last six months . Methods: Single centre experience; Here we presented six patients who were followed up in Nephrology clinic with acute kidney injury (AKI) due to synthetic cannabinoid usage in last six months . Results: Six male patients aged between 28-42 years were admitted to the nephrology clinic, after presenting to the ER with nausea, vomiting and abdominal pain and whose laboratory results showed high levels of urea and creatinine. Clinical and laboratory findings in all six patients are summarized in Table 1. The most evident complaints of patients were nausea and vomiting. The patients declared that nausea-vomiting started approximately 10-16 hours before coming to the ER and approximately 2-4 hours after inhalation. All 6 cases have abdominal pain starting from the epigastric region and felt more severely in both lumbar regions. Metabolic alkalosis was observed in 4, normoacidemia in 2 patients. Kidney biopsies were performed in 2 of the cases (Case 3 and 5) revealed evidence of acute tubular necrosis, focal tubular atrophy, flattened and granulated epithelium and interstitial fibrosis. On the other hand; hypertrophic and global sclerotic glomerulies were observed. Vessels were unremarkable, with no significant staining on the immunofluorescence. Conclusions: SCs using is growing up daily, particularly in young generation and becoming a serious public health threat. In less than 6 months, a total of 6 cases were hospitalised in our clinic and unfortunately 4 of them (%66) became dependent on

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