SUMMARY BackgroundControversy exists surrounding the optimal treatment for inducing remission in active Crohn's disease.

Original ArticleContinuous subcutaneous insulin infusion vs. multiple daily injections in children with type 1 diabetes: a systematic review and meta-analysis of randomized control trialsPań kowska E, B1azik M, Dziechciarz P, Szypowska A, Szajewska H. Continuous subcutaneous insulin infusion vs. multiple daily injections in children with type 1 diabetes: a systematic review and meta-analysis of randomized control trials. Pediatric Diabetes 2009: 10: 52-58.Objective: To investigate potential effects of continuous subcutaneous insulin infusion (CSII) compared with multiple daily injections (MDI) on glycemic control in children with type 1 diabetes mellitus (T1DM). Study design: Meta-analysis and systematic review of randomized control studies (RCTs). The electronic databases MEDLINE, Cochrane Library, and EMBASE were searched through October 2007. Results: Six RCTs involving 165 participants with T1DM met our predefined inclusion criteria. Combined data from all trials showed that the CSII group compared with the MDI group experienced a significant reduction in the level of glycosylated hemoglobin. The pooled weighted mean difference (WMD) was 20.24% [95% confidence interval (95% CI) 20.41 to 20.07, p , 0.001] with a fixed model and remained significant in the random effect model. This effect was reached by slightly decreasing insulin requirement [three RCTs, n ¼ 74, WMD 20.22 IU/kg/d (95% CI 20.31 to 20.14, p , 0.001)]. No differences in the incidences of ketoacidosis and severe hypoglycemic events were found. Conclusions: In short-term insulin therapy, CSII compared with MDI is a more effective form of metabolic control and allows reducing the daily insulin requirement. Yet, no conclusions have been made so far whether this effect holds in later years. These results should be approached with caution because of the methodological limitations of the analyzed studies.

SUMMARY BackgroundFunctional abdominal pain disorders (FAPD) are common in schoolaged children; however, there is no reliable treatment.

This meta-analysis shows that thickened food is only moderately effective in treating gastroesophageal reflux in healthy infants.

SUMMARY BackgroundA lack of reliable treatments for abdominal pain-related functional gastrointestinal disorders prompts interest in new therapies.