The experiment entitled “Impact of different tillage and nutrient management strategies on productivity and profitability of direct seeded rice (Oryza sativa L.)” was conducted in an ongoing trial at the Agronomical Research Farm (plot no. 5) of Tirhut College of Agriculture, Dholi (RPCAU, Pusa) during Kharif 2019. The experiment was laid out in a ‘split-plot design’ with tillage practices under main plot treatments and nutrient management practices as subplot treatments. The results revealed that both tillage and nutrient management practices significantly influenced all the growth parameters of rice. Significantly higher plant height, no. of tillers/m2, dry matter production and superior CGR at all the stages of crop growth were recorded in Zero tillage + Residue management over conventional tillage among tillage practices which was statistically at par with Zero tillage and in SSNM based on Nutrient expert over RDF among nutrient management treatments which was statistically at par with 60 % RDN + GSGN + 100% PK of RDF. Zero tillage + Residue management and Zero tillage increased the grain yield of direct seeded rice to the tune of 14.03 and 10.15 per cent over Conventional tillage, respectively. While SSNM based on Nutrient expert and 60 % RDN + GSGN + 100% PK of RDF increased grain yield of direct seeded rice to the tune of 14.91 and 12.07 per cent over RDF, respectively.