A B S T R A C T Recent advances in the processing technology are permitting the manufacture of novel metallic materials with superior fatigue properties via microstructure tailoring. In the light of these promising developments, there is a rising need for establishing a synergy between state-of-the-art experimental characterizations and physically based theoretical underpinnings. A revisit to the existing predictive literature is thus a timely requirement prior to furthering new design guidelines against cyclic damage. To that end, this paper recounts an overview of the key mechanistic and analytical theories on the fatigue crack growth mechanisms. Emphasis is placed on categorizing the proposed modelling endeavours based on their fundamental principles. In doing so, contributions and limitations thereof are carefully examined on the basis of most updated experimental revelations. The objective is to provide a perspective to the current generation of engineers and researchers alike. This concise yet critical narrative would essentially assist in formulating even more advanced microstructure-damage relationships in the modern context. A commentary is added at the end outlining the promising avenues for future research.CTOD, FCG = crack tip opening displacement, fatigue crack growth MD, DFT = molecular dynamics, density functional theory RVE = representative volume element LEFM, EPFM = linear elastic and elastic plastic fracture mechanics E, H = Young's modulus, plastic modulus GB = grain boundary K max , K min , K open , = maximum, minimum and opening stress-intensity factors K c = fracture toughness under mode I loading ΔK eff th , ΔK th = (effective) threshold stress intensity factor range da/dN = fatigue crack growth rate per cycle (a is the crack length and N is the number of cycles) L deflect , θ deflect = length and angle of a deflected crack respectively θ = angle between slip and crack paths σ yield , σ cyclic yield , σ fracture = monotonic, cyclic yields strengths and static fracture strength σ ′ f , ε ′ f = strength and ductility coefficient in Coffin-Manson-Basquin rule: Δε plastic ¼ 2ε ′ f 2N f ð Þ c σ eff , σ hydro = effective and hydrostatic stress ρ * = effective radius of a sharp crack ρ slip , _ ρ vacancy , ρ interface = dislocation density, vacancy generation rate and interface density P H 2 , P O 2 = partial pressures of hydrogen and oxygen m, C = Paris exponent, Paris proportionality constant m Schmid = Schmid factor τ friction , τ forward friction , τ reverse friction = friction (Peierls) stress for free (unobstructed), forward and reverse dislocation glide