A 9-year-old boy presented with asymptomatic, skin colored, grouped papules with mild scaling on elbows, buttocks, knees, and dorsa of feet in a bilateral symmetric manner for 8 months (Fig. 1). There were no systemic features and boy appeared otherwise healthy. Family history was non-contributory. Mantoux text was positive (20 X 24 mm); routine blood investigations, chext X-ray and abdominal ultrasonography were normal. Histopathological findings were consistent with lichen scrofulosorum (Fig. 2). He showed almost complete resolution of lesions after four months of anti-tubercular therapy.

No abstract

Paternally transmitted damage to offspring is recognized as a complex issue. Each parent contributes 23 chromosomes to a child; hence, it is necessary to know the effects of both maternal and paternal pre-and peri-conceptional exposure to drugs on pregnancy outcome. While there are many studies on the effects of maternal drug exposure on pregnancy outcome, literature on paternal exposure is scarce. Of late however, paternal exposure has been receiving increasing attention. We present a brief review on the safety of commonly used drugs in dermatology, focused on retinoids, immune suppressants, anti androgens and thalidomide.

Toxic epidermal necrolysis (TEN) is a severe life-threatening adverse drug reaction that predominantly involve the skin and mucous membranes, and is associated with high mortality (25-35% or even higher) and with various long term sequelae. There is no universally accepted treatment for TEN, but key elements of management include rapid diagnosis, identification and interruption of the culprit drug, evaluation of the prognosis using SCORTEN, specialized supportive care ideally in an intensive care unit, and consideration of immunomodulating agents. Cyclosporine has recently emerged as a promising immunomodulating agent in the management of TEN and we have performed a brief review of evidence highlighting its role in TEN management.

No abstract