ImportanceThe Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) randomized clinical trial sought to recruit 50 000 adults into a study comparing colorectal cancer (CRC) mortality outcomes after randomization to either an annual fecal immunochemical test (FIT) or colonoscopy.ObjectiveTo (1) describe study participant characteristics and (2) examine who declined participation because of a preference for colonoscopy or stool testing (ie, fecal occult blood test [FOBT]/FIT) and assess that preference’s association with geographic and temporal factors.Design, Setting, and ParticipantsThis cross-sectional study within CONFIRM, which completed enrollment through 46 Department of Veterans Affairs medical centers between May 22, 2012, and December 1, 2017, with follow-up planned through 2028, comprised veterans aged 50 to 75 years with an average CRC risk and due for screening. Data were analyzed between March 7 and December 5, 2022.ExposureCase report forms were used to capture enrolled participant data and reasons for declining participation among otherwise eligible individuals.Main Outcomes and MeasuresDescriptive statistics were used to characterize the cohort overall and by intervention. Among individuals declining participation, logistic regression was used to compare preference for FOBT/FIT or colonoscopy by recruitment region and year.ResultsA total of 50 126 participants were recruited (mean [SD] age, 59.1 [6.9] years; 46 618 [93.0%] male and 3508 [7.0%] female). The cohort was racially and ethnically diverse, with 748 (1.5%) identifying as Asian, 12 021 (24.0%) as Black, 415 (0.8%) as Native American or Alaska Native, 34 629 (69.1%) as White, and 1877 (3.7%) as other race, including multiracial; and 5734 (11.4%) as having Hispanic ethnicity. Of the 11 109 eligible individuals who declined participation (18.0%), 4824 (43.4%) declined due to a stated preference for a specific screening test, with FOBT/FIT being the most preferred method (2820 [58.5%]) vs colonoscopy (1958 [40.6%]; P < .001) or other screening tests (46 [1.0%] P < .001). Preference for FOBT/FIT was strongest in the West (963 of 1472 [65.4%]) and modest elsewhere, ranging from 199 of 371 (53.6%) in the Northeast to 884 of 1543 (57.3%) in the Midwest (P = .001). Adjusting for region, the preference for FOBT/FIT increased by 19% per recruitment year (odds ratio, 1.19; 95% CI, 1.14-1.25).Conclusions and RelevanceIn this cross-sectional analysis of veterans choosing nonenrollment in the CONFIRM study, those who declined participation more often preferred FOBT or FIT over colonoscopy. This preference increased over time and was strongest in the western US and may provide insight into trends in CRC screening preferences.

S7after excision. Diagnosis is based on clinical and histopathological study of injuries. Case Report: 67 years old woman, smoker of 40 cigarettes a day for over 40 years with no medical history of interest. The patient has whitish lesions, asymptomatic, of rough appearance on both jugal mucosa, hard palate, floor of the mouth, ventral surface of the tongue and tonsillar pillars since 5 years ago. We decided to biopsy lesions of the ventral surface of the tongue and floor of mouth. The pathology revealed Stomatitis interface with moderate dysplasia. After of 12 months of checkups with no injuries found, we decided to undergo a new biopsy obtaining a Squamous Cell Carcinoma In situ. We referred to the Maxillofacial Service for surgical excision of the lesions. Conclusion: PVL is a very dangerous disease because of its high percentage of malignant, difficult and controversial treatment monitoring, and questionable effectiveness.

The 69-year-old female patient was referred to our Service presenting with a two-moth history of painless mass in the right parotid gland. The medical history of the patient includes a treatment for arterial hypertension, dyslipidemia and a surgical thyroidectomy. A 1.5 cm lump, soft in consistency and movable when palpated, was observed during the physical examination. A supplementary ultrasound and NMR were requested, the visualization of which resulted in a diagnosis of suspected WT. After the supplementary trials, the patient was briefed and the possibility was pondered considering her age and general condition at the moment of the parotidectomy. Conclusion: WT is a relatively frequent entity, and odontologists must be aware of its clinical manifestations and most relevant diagnostic tests.-Oral Presentation 67 TITLE: Osteonecrosis generated by the use of Bisphosphonates in geriatric patients. A case report AUTHORS:

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Cardiovascular disease is the most common cause of death among elderly patients. Treatment and prevention is based on antiplatelet and anticoagulant therapy, which increases the risk of bleeding after surgical procedures in the oral cavity. The aim of this paper is to give an up to date dental management protocol of these patients. Materials and Methods: A literature review was conducted in search engines as Medline-Pubmed and Embase using the following keywords: anticoagulants, antiplatelet, dental management and oral surgery. We included studies published in Spanish and English from 2013 until now. Results and Discussion: The current trend among patients receiving antiplatelet therapy is to maintain treatment during the surgical procedures, and ensuring a good control of bleeding with local hemostatic measures. There is no clear protocol to follow with new anticoagulated patients, although most studies make some recommendations. Conclusions: Even though there are current recommendations and protocols, it is always recommended to contact the patient´s primary care physician before any invasive procedures.