The relative importance of polar and steric influences on the course of the acid-catalysed opening of several epoxycholestanes bearing a vicinal cis-hydroxy-or -acetoxy-group has been investigated.
Some reactions of Nic-1 (nicandrenone) (2a). the main steroidal component of Nicandraphysaloides (Solanaceae), and its relation to the steroidal lactones of the withanolide group are discussed.
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