Peptic ulcer is a chronic recurrent disease, accompanied by alternating periods of exacerbation and remission, its main feature is the formation of an ulcer in the wall of the stomach and (or) duodenum, penetrating – in this difference from superficial damage to the mucous membrane (erosions) – into the submucosal layer. The etiology is the appearance of Helicobacter pylori (H. pylori) falling into favorable conditions with weakened microfl and the presence of aggressive factors from the environment. In the pathogenesis of peptic ulcer disease, thinning of the gastrointestinal mucosa and violation of compensation mechanisms at the local level are of paramount importance. An important role in the diagnosis is given to a carefully collected anamnesis and complaints of the patient, supplemented by physical examinations, laboratory and instrumental examination methods. The treatment of patients is based on modern methods of treatment, where the latest drugs with proven effi  and well-proven in clinical practice are used, consistent with the international recommendations of the Maastricht V / Florence Consensus, where anti-helicobacter therapy is mandatory for patients with peptic ulcer and chronic gastritis. Currently, treatment is still based on a combination of antimicrobial agents (amoxicillin, clarithromycin, metronidazole), and antisecretory agents (proton pump inhibitors). Standard triple therapy, which includes PPIs and two antibiotics (clarithromycin and amoxicillin/metronidazole) are widely used as a main-line regimen for the treatment of infection. In addition, the concomitant use of alternative medicine is important for the emergence of adaptive or synergistic effects against H. pylori infection.

Itsenko-Cushing’s disease is a disease characterized by dysfunctions of the hypothalamic-pituitary-adrenal system. Without therapy during the first five years, the survival rate is 50 %, and the patient’s condition improves markedly with palliative treatment, increasing the survival rate to 86 %. Today, there are a number of criteria for the diagnosis, diagnosis and treatment of this pathology.

Stress-induced cardiomyopathy is a disease that entails a transient violation of the systolic and diastolic functions of the left ventricular myocardium with subsequent enlargement of the heart chambers, akinesia of the apical and middle segments and normo- or hyperkinesia of the basal segments in the absence of pronounced hemodynamic stenosis of the coronary arteries. To date, there is no reliable information about the pathogenesis, methods of therapy and possible prognosis of this disease, so there is a need for further research.