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A simple, convenient and efficient synthetic approach for the synthesis of (15S) bimatoprost (4) via lipase enzyme mediated stereo selective reduction from chiral precursor Corey lactone diol as substrate was described. Swern oxidation, lipase enzymatic reduction and Wittig reaction conditions are used as key steps for the synthesis of bimatoprost. This method was found to be an efficient with considerable yield, cost effective and minimized the synthetic steps compared to reported procedures.

Complex GenericsA complex generic product is a medicine that can be prescribed as a substitute for the originator specialized product because the bioequivalence has been demonstrated; however it is not as simple as generics to get manufactured. To be "complex generic", a medicinal product must preliminarily exhibit not

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