Primary Cutaneous Diffuse Large B Cell Lymphoma, Leg Type (PCDLBCL, LT) comprises 4% of all cutaneous lymphomas, and it presents as an aggressive form of lymphoma. Rarely do pathologist/cytologists find specimens of PCDLBCL, LT on Fine Needle Aspiration Cytology (FNAC). The mimickers on FNAC are metastatic small cell carcinoma, Merkel Cell Carcinoma (MCC), Malignant Melanoma (MM), Cutaneous Alveolar Rhabdomyosarcoma and Primary Cutaneous Ewing's Sarcoma (PCES). A 75-year-old female patient presented in the Department of Surgery with multiple nodules on the leg for three months. On cytology small round cell tumour with possibility of non hodgkin lymphoma was given and biopsy was advised. The confirmation of PCDLBCL, LT on cytology is not recommended however, it is emphasised that it can be picked up on FNAC and distinguished from its mimickers. Because of the aggressive nature and poor prognosis with the frequent relapses and tendency for extracutaneous spread, it is considered to be a distinct type of cutaneous lymphoma which needs to be diagnosed and treated as early as possible.
Background: Cytologic examination of specimens obtained from the respiratory tract is the primary and frequently used diagnostic technique in patients with respiratory symptoms or in those presenting with a pulmonary abnormality. Lung carcinoma is the leading cause of mortality in India. Hence, early diagnosis and effective treatment are keys to prolong the survival of lung cancer patients.
Methods: 100 consecutive samples were taken which included 66 samples of bronchial wash, 27 samples of brush and 7 samples of bronchoalveolar lavage. These were viewed independently by two pathologists to study the ease of applicability, reproducibility and role of Papanicolaou Society of Cytopathology classification for pulmonary specimens.
Result: The classification and terminology scheme recommend a six-tiered system comprising of non-diagnostic, negative, atypical, neoplastic (benign and neoplasms of low malignant potential), suspicious and positive for malignancy. In our study 43% were non-diagnostic, 33% were negative, 10% were atypical, 6% were suspicious for malignancy and 8% were malignant.
Conclusion: This classification system of respiratory cytology is easy to apply and interpret with minimal inter-observer variation. Standardized classification and terminology system provide a framework for consistent inter-intra departmental and inter institutional communication of diagnostic, prognostic and management information needed for consistent and optimal patient care.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.