Phenolic compounds (like 4-nitrophenol) and dyes (like methyl orange) are common by-products discharged by many industries as wastes; they are toxic and may induce discomfort and irritation in humans when ingested. Most of these compounds can be made less toxic through catalytic degradation. Metal oxide nanoparticles are found to have high catalytic activity and can degrade toxic phenolic compounds and dyes. In the current study, pomegranate rind extract was used for the green synthesis of iron oxide nanoparticles that exhibited an octahedron morphology revealed by scanning electron microscopy analysis. Energy dispersive x-ray analysis showed 47.96% content of Fe (by weight); high resolution-transmission electron microscopy analysis confirmed that the nanoparticles had a particle size of 22.54 ± 4.13 nm. The particles were further characterized by x-ray diffraction, fourier transform-infrared spectroscopy, vibrating sample magnetometer, and thermogravimetric analysis. The nanoparticle proved to be efficient in reducing 4-nitrophenol and methyl orange. It was also found to be non-toxic towards murine macrophages, RAW 264.7 with good ROS-scavenging potential compared to control.

Objectives: Madhuca longifolia is a versatile tropical tree mostly cultivated or harvested in the wild in South Asia for its edible flowers and oil seeds. Mahua trees are vegetatively propagated; they act as soil improvers, and also help in soil reclamation and erosion control. M. longifolia is a plant of great importance due to its scientifically proven uses such as antioxidant activity, immune suppression, and neuroprotective activity, which is because of the various chemical constituents present in different parts of the plant. The aim of our study is to analyze the absorption, distribution, metabolism, and excretion (ADME) properties and pathways analysis of active components of M. longifolia. Methods: The detailed study of these chemical constituents is done using PubChem and software’s such as Rasmol and Pymol. Swiss ADME was used to find out the ADME properties of the chemical constituents present in the plant. The pathway analysis was done using a literature survey and Swiss TargetPrediction. Results: The research has identify the potentially active compound from the plant with its inhibitory target protein. Conclusion: The ADME result demonstrates the potential pharmacological activity of the plant compound, which can be studied through in vivo model against its potential inhibitory target molecules.

Introduction: Parkinson's disease (PD) is a progressive neurological disorder that affects both motor and non-motor skills in an individual. Both familial and sporadic cases of PD can be caused by mutations in the LRRK2, PARK7, PINK1, PRKN, or SNCA genes. However, mutations in genes PINK1 and LRRK2 are associated with early onset PD. Case presentation: This study reports an 18-year-old female with early onset PD, where whole-exome sequencing showed a pathogenic missense variant p.R88W in the PINK1 gene (NM_032409.2) resulting in the disease condition. Conclusion: For cases like neurodegenerative disorders confirmed by an MRI or CT scan, it is always advisable to perform whole-exome sequencing or next-generation sequencing to detect the genes associated with the disease. Depending on the type of the symptoms, medication along with physical therapy can be advised to manage the condition.