this study examined enacted stigma and problem substance use among asian sexual minority youth and the buffering role of protective factors. logistic regression analyses of a weighted sample of 5,423 asian youth who completed the 2003 Bc adolescent health survey indicated that sexual minority youth were more likely to be victimized compared to heterosexual peers. Furthermore, protective factors, such as involvement in extracurricular activities or healthy connections to peers or school, reduced the likelihood of problem substance use, even among stigmatized youth. the study highlights the need to create safe, supportive school and community environments for asian sexual minority adolescents.