This narrative review of the literature aims to assess the impact of COVID-19 on the younger age group in terms of the Global mortality of COVID-19 in comparison to Nepal. An extensive literature survey of English literature was conducted using Pubmed, Medline, Google Scholar, Embase, WHO Nepal Situation Updates on COVID-19, Situation update report, Ministry of Health and Population-Nepal from January 25, 2020 to June20, 2020. According to the Ministry of Health and population of The Government of Nepal, as of June 20 , 2020, out of a total of 8,605 laboratory confirmed cases reported to date, the pattern shows that most of the cases fell into the cohort of 21-30 years (37.72%), followed by 11-20 years (24.35 %), 31-40 years (21.97%) and 41-50 years (9.2%). To date Nepal has recorded a total of twenty-two deaths. At first evaluation thesefigures may not strike one as alarming, but on further investigation it is noted that the mean age is 42. 32 ± 19.632 SD years, and out of which male patients accounted for 77.3% and female accounted for 22.7%. The current situation of COVID-19 and how it develops in Nepal should be closely monitored and could be of international concern as it may be the early indicator of a changing pattern in COVID-19 infections. Nepal maytherefore act as a global watch dog, due to the fact that the world could very possibly expose the younger age group under the notion that they are more resilient to the virus, when in reality that notion may be changing. This trend must be monitored and further investigated in order to establish the risk of the events unfolding in Nepal.

COVID-19 remains a threat to the entire world. In an attempt to curb its spread and facilitate its treatment, the technological tool that is Artificial Intelligence (AI) is being researched as a potential alternative to conventional methods. Industrial Revolution 4.0 marks the dawn to the combination of digital, physical and biological systems, by application of digital skills such as Blockchain, Internet of things, Artificial Intelligence and Big data. AI tools in SARS-COV-2 pandemic are highly competitive to human performance, such as rapid screening and diagnosis of the disease, surveilling the efficacy of the treatment, keeping record and depicting active cases and mortality, inventions of medications and vaccines, relieving the workload of healthcare workers and extinguishing the spread of the disease. Contact tracing platforms like Aarogya Setu App, implemented by the Government of India, Australian Government's COVID Safe app, Trace Together- a Bluetooth-based contact tracing app developed in Singapore; based on syndromic mapping/surveillance technology. Artificial intelligence will become a mainstay in both the diagnosis and treatment of COVID-19 as well as similar pandemics in future. The application and system development will be challenging; the accuracy and rapidity of its use far outweigh this drawback. The current global technological leaders have proven that the retro modification of current data systems and applications have been indispensable in the war on COVID-19, thus permanently securing their development and application in future.

Background: SARS-CoV-2 is the highly infectious new coronavirus, which has been associated with the pandemic COVID-19. The majority of those pathogenic coronaviruses are benign, namely HCoV-229E, HCoV-NL63, HCoV-OC43 and HCoV-HKU1, and they have been linked to common cases of flu. Two of these viruses namely SARS coronavirus and MERS coronavirus are known to have caused more severe infections. Based on phylogenetic analysis, the Coronaviruses are divided into four groups, which are: Alpha-CoV, Beta -CoV, Gamma-CoV, and Delta -CoV. The Beta- CoV genus is further classified into four lineages, which are referred to as Groups A, B, C, and D. At the genomic level, SARS-CoV-2 has been identified to match with the lineage B of Beta coronavirus. This infection affects the respiratory tract, mainly the lungs' alveoli, and can cause a wide variety of symptoms ranging from discharge from the nose and a sore throat to respiratory distress, septic shock, and failure of multiple organs. To date, millions of people have been affected by the virus. The current mortality rate is around 6%. Early diagnosis is essential to prevent the spread of the infection.  An extensive literature review was done using Pubmed, Medline, Pubmed Central, Embase, Goggle Scholar databases from January 20, 2020, till October 20, 2020. Conclusion: COVID-19 is the third outbreak of a pathogenic human coronavirus, after MERS and SARS. Its high rate of transmissibility has taken a toll on citizens' personal and professional lives globally. The peculiarities of SARS-CoV-2, regarding its genomic uniqueness and the role of Malayan pangolins as intermediate hosts, still demands more research to determine the degree to which they partake in the generation of the pathogenicity and infectiousness of the virus.

Background: The objectives of the study were to identify the psychological impact of lockdown on medical students due to COVID-19 and to discover the educational perplexities being faced by these students during the lockdown due to COVID-19. Methods: A cross-sectional study was conducted at Sir Seewoosagur Ramgoolam Medical College (SSRMC), Mauritius. Questions were designed after extensive review of the literature, so that they were relevant to meet the objectives of the study. Results: Out of 700 undergraduate medical students, 663 students participated in the study, this equates to a substantial response rate of 95%. Due to the pandemic 348 (52.5 %) of the students were stationed in their hometown and the remaining 315 (47.5 %) were stationed in Mauritius. 464(70%) of the students suffered from the psychological impact of lockdown whereas 634(95.6%) of the students suffered from the educational impact of lockdown. Mauritian students suffered from a greater educational impact aOR4.236[1.606-11.173]. Psychological impact aOR 1.280 [0.917-1.789] and educational impact aOR 2.464 [1.076-5.647] was found more in students those who were at their hometown. Conclusion: Lockdown triggered both educational and psychological impact on medical students. On a psychological basis it was proven that the lockdown induced a feeling of guilt and had subsequent psychological impacts in certain students. The COVID-19 situation was simultaneously indicated to be a motivator in the majority of students; however, juxtaposed to this was the fact that various students felt as if they could not study at the same level that they are accustomed to due to the uncertainty of the situation.

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