DNA is emerging as an increasingly attractive medium for data storage due to a number of important and unique advantages it offers, most notably the unprecedented durability and density. While

Probabilistic graphical models have emerged as a powerful modeling tool for several real-world scenarios where one needs to reason under uncertainty. A graphical model's partition function is a central quantity of interest, and its computation is key to several probabilistic reasoning tasks. Given the #P-hardness of computing the partition function, several techniques have been proposed over the years with varying guarantees on the quality of estimates and their runtime behavior. This paper seeks to present a survey of 18 techniques and a rigorous empirical study of their behavior across an extensive set of benchmarks. Our empirical study draws up a surprising observation: exact techniques are as efficient as the approximate ones, and therefore, we conclude with an optimistic view of opportunities for the design of approximate techniques with enhanced scalability. Motivated by the observation of an order of magnitude difference between the Virtual Best Solver and the best performing tool, we envision an exciting line of research focused on the development of portfolio solvers.

The runtime performance of modern SAT solvers is deeply connected to the phase transition behavior of CNF formulas. While CNF solving has witnessed significant runtime improvement over the past two decades, the same does not hold for several other classes such as the conjunction of cardinality and XOR constraints, denoted as CARD-XOR formulas. The problem of determining satisfiability of CARD-XOR formulas is a fundamental problem with wide variety of applications ranging from discrete integration in the field of artificial intelligence to maximum likelihood decoding in coding theory. The runtime behavior of random CARD-XOR formulas is unexplored in prior work. In this paper, we present the first rigorous empirical study to characterize the runtime behavior of 1-CARD-XOR formulas. We show empirical evidence of a surprising phase-transition that follows a non-linear tradeoff between CARD and XOR constraints.

Probabilistic graphical models have emerged as a powerful modeling tool for several real-world scenarios where one needs to reason under uncertainty. A graphical model's partition function is a central quantity of interest, and its computation is key to several probabilistic reasoning tasks. Given the #Phardness of computing the partition function, several techniques have been proposed over the years with varying guarantees on the quality of estimates and their runtime behavior. This paper seeks to present a survey of 18 techniques and a rigorous empirical study of their behavior across an extensive set of benchmarks. Our empirical study draws up a surprising observation: exact techniques are as efficient as the approximate ones, and therefore, we conclude with an optimistic view of opportunities for the design of approximate techniques with enhanced scalability. Motivated by the observation of an order of magnitude difference between the Virtual Best Solver and the best performing tool, we envision an exciting line of research focused on the development of portfolio solvers.