3Large-scale whole cancer-genome sequencing projects have led to the identification of a demonstrated that very large cancer cohorts will be required in order to identify low 2 6 frequency non-coding drivers. To further this endeavour, in this study, we performed high-2 7 depth sequencing across 95 colorectal cancers and matched normal samples using a unique elements. We first assessed coverage and variant detection capability from our TCS data, and 3 0 compared this with a sample that was additionally whole-genome sequenced (WGS). TCS 3 1 enabled substantially deeper sequencing and thus we detected 51% more somatic single