No abstract

No abstract

No abstract

The βsite amyloid precursor protein cleaving enzyme 1 (BACE1), also known as βsecretase, is mainly expressed in the neurons of brain. It is a transmembrane aspartylprotease, responsible for producing toxic amyloid-β (Aβ) from amyloid precursor protein (APP), which is a pathological hallmark in Alzheimer's disease (Kumar et al., 2018). The cascade proteolytic cleavage of APP is led by BACE1 and followed by γsecretase, which leads to the production and release of amyloid-β peptide (Coimbra et al., 2018). The initial cleavage of APP by BACE1 yields