The aim of this study was to compare stimulated whole saliva flow rate and composition of menopausal women with/without oral dryness (OD) feeling. A case-control study was carried out in 42 selected menopausal women aged 52-73 years with or without OD feeling (21 as case and 21 as control) conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Paraffin-stimulated saliva samples were obtained by expectoration. The stimulated whole saliva composition was measured by a spectrophotometer [magnesium (Mg(+2)), calcium (Ca(+2)), chloride (Cl(-)), inorganic phosphate (Pi) and total protein], flame-photometry [sodium (Na(+))] and ion selective electrode (ISE) [potassium (K(+))] methods. No significant differences were found in stimulated whole saliva flow rate, Mg(+2), Cl(-), Pi, Na(+), K(+) and total protein concentrations between the two groups, but the mean calcium concentration was significantly higher in cases than in controls (P = 0.003). It seems that the level of salivary calcium concentration may be higher in menopausal women with OD feeling than in the control group.