Introduction: Non-alcoholic fatty liver disease (NAFLD) has emerged as a major public health problem in recent times. It is one of the neglected conditions in developing nations like India, due to scarcity of studies on the subject. Study objective was to assess the prevalence of NAFLD among patients undergoing master health checkup in a tertiary care teaching hospital and to analyze the profile of NAFLD cases. Material and materials: The study was a hospital based analytical cross-sectional study. Conducted in a tertiary care teaching hospital in south India. People attending the master health checkup in the study setting from June 2015 to July 2018 were included. Chi square test was used to test statistical significance. Results: A total of 818 patients were included, out of whom 130(15.89%) had NAFLD. The proportion of grade 1, 2 and 3 fatty liver was 79.23%, 13.84% and 6.92% respectively. The difference in waist circumference and HDL values were statistically significant between male & female (P value <0.001 and 0.007 respectively). No other components of Metabolic syndrome had shown statistically significant difference between males and females. The difference in grade of NAFLD across the age group is found to be significant with a P-value of 0.035. Grade of NAFLD was not associated with any other diet or lifestyle related parameters. Conclusions: Significant proportion of healthy subjects are affected by NAFLD, some of them with severe grades, with key gender differences in some of the factors associated with NAFLD. Patients and clinicians needs to be sensitized regarding NAFLD.

Background: IMT assessment as a non-invasive imaging test is quite widely used especially among RA patients, the clinical applications of using such knowledge is scarce, hence study was conducted to compare the carotid artery intima-media thickness (CIMT) in patients with rheumatoid arthritis (RA) with healthy controls also to study the correlation between duration of rheumatoid arthritis, the activity of rheumatoid arthritis and other factors influencing (CIMT).Methods: In analytical cross-sectional study, of 80 participants of RA and 40 healthy controls, “DAS28” was used to assess disease activity.  Carotid intima-media thickness assessed using carotid ultrasonography.Results: Mean age of the cases and controls was 43.9 and 44.38 years. Subjects with duration of disease <2 years, to 5 years and >5 years were 35%, 45% and 20%. The mean carotid intima-media thickness was 5.61mm in controls, and CIMT was 6.11mm in people below 2 years and 7.08 mm in people between 2 to 5 years and 8.00mm in people above 5 years which was statistically significant. The mean carotid intima-media thickness was 5.61mm controls and 6.86mm in people with low, 7.00mm in people with moderate and 6.95mm in people with high disease activity, which was statistically significant.Conclusions: Study findings revealed risk of increase in carotid intima-media thickness higher among RA patients in the later stages and can increase the patients’ susceptibility to cardiovascular events. The factors showing strong association with intimal medial thickness were the age and symptoms duration.

Background: Type 2 DM is characterized by increased platelets activation, hence platelet functional markers like the mean platelet volume (MPV) can play a vital role in identifying subjects at high risk of developing microvascular complications. Objectives: To study the association between mean platelet volume and micro albuminuria and to analyse factors associated with MPV in patients with Type 2 diabetes mellitus. Materials & Methods: A cross sectional study was conducted in the department of internal medicine, Velammal medical college and hospital, between June 2016 and December 2016. Subjects with DM, with age > 20 years were included. Latex Turbidimetric method was used to assess urine micro albumin. Results: A total of 269 diabetic patients with mean duration of disease of 4.84 years were included. There was a moderate, statistically significant positive correlation between HbA1 C level and Mean platelet volume (PCC=-0.198, p value 0.001). The other factors had shown no statistically significant correlation with MPV. There was a Statistically significant mild negative correlation between serum uric acid and MPV (PCC=-0.196, p value 0.001). The mean MPV in people with low and high Urine micro albumin was 7.716 ± 0.876 and 7.705 ± 0.890 respectively, and the difference was statistically not significant. Concussions: Poor glycaemic control may lead to higher MPV in diabetic population. Very minimal and statistically non-significant difference was observed in mean MPV value between subjects with high micro albuminuria and low micro albuminuria.