With the continuous enhancement in the speed and architecture of mobile processors it has become possible to play even high resolution videos on them. However the compilers have lagged behind in taking full utilization of the processing capabilities of the underlying hardware. H.264, known for its high compression ratio and computational complexity, needs performance optimizations for a computationally constraint environment. Some of these techniques are described in this paper.Index Terms-H.264 video decoder, Cortex Optimizations, cache optimizations.

Background: Hydroxyurea therapy is a known effective and safe therapy for the treatment of sickle cell anemia (SCA). Although it is used worldwide in our Indian based setup, it is underutilized not only due to economic reasons but also due to unaware practitioners about its use.Methods: An ambispective observational study was performed at our tertiary care center over a period of 1 year 8 months. One hundred and ninety patients were enrolled after taking a complete history, then started on Hydroxyurea and followed up every 2 months till 1 year. On follow-up, frequency of vaso-occlucive crisis, blood transfusion and hospitalization were noted along with routine investigations and for any side effects.Results: Of 190 total recruited patients, 84 were studied at the end because of loss to follow-up due to various reasons. Significant decrease in the frequency of vaso-occlusive crisis (VOC), blood transfusion and hospitalisation were observed within 1 year of starting hydroxyurea (p<0.05).Conclusions: The use of hydroxyurea in our native population at our setup can decrease the frequency of vasooccluisve crisis, blood transfusion and hospitalisation in sickle cell patients.

Background: Acute encephalitis syndrome (AES) is defined as a person of any age group, at any time of the year with the acute onset of fever and change in mental sensorium (including confusion, disorientation, coma or inability to talk) and/or new onset of convulsions (excluding febrile seizures). Encephalitis is a inflammation of brain tissue which presents as a diffuse and/or a focal neuropsychological dysfunction and inflammation of adjacent meningitis. Objectives were to determine clinicoepidemiological profile in AES with special to reference cerebral malaria and to study various MRI findings in patients of AES especially in cerebral malaria.Methods: A prospective study of all cases of fever with unconsciousness or altered sensorium with or without convulsions admitted in PICU of MYH and CNBC Indore. Inclusion criteria was all those children who were previously neurologically normal, of age 1-14 years, patients with fever (<15days) with altered sensorium, with or without seizures and who stay in hospital long enough to complete essential diagnostic work up which includes (CBC with peripheral smear, RFT, LFT, MP, S. electrolytes, CSF, MRI brain).Results: The final study group comprised of 60 patients with age group 1-14 yrs and male to female ratio was 1.07:1. Patients with diagnosis of cerebral malaria were 17. High grade fever, headache, altered sensorium, generalized seizures In general examination pallor was present in 52.9%, icterus in 35.29% cases of cerebral malaria. Splenomegaly (70.5%) was more common finding than hepatomegaly (58.8%) in cerebral malaria. GCS was>6 in most cases, fundus abnormality and meningeal irritation was absent in all cases of cerebral malaria. MRI of brain in cerebral malaria was mostly normal, in (47.05%), second most common we get hyperintensity in periventricular and corpus callosum areas (23.52%), hyperintensity in basal ganglia and thalamus was found in17.64% cases and white matter changes in 2 cases. The final outcome of all cerebral cases was good, all were discharged, and there was no mortality.Conclusions: Our result demonstrate that cerebral malaria is a common cause of acute febrile encephalopathy in children. Presence of plasmodium falciparum is essential for diagnosis of cerebral malaria. No specific lesions have been identified in MRI brain.

To evaluate the ability of four types of the risk of malignance indices (RMI) based on serum levels of Ca-125, ultrasound score and menopausal status to discriminate between benign and malignant ovarian tumours. Methods: it was a Prospective cross sectional Study conducted in the Department of Obstetrics and Gynecology. During this study 300 women were enrolled in the study over a period of 1 1/2 years (December 2015-July 2017). The RMI was evaluated for sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) with reference to the actual presence of a malignant or benign pelvic tumour. Results: In this study out of 300 patients with clinically suspected ovarian tumours were included. RMI 1,2,3,4 was calculated according to their formula. Sensitivity of RMI-1, 2, 3 and 4 was calculated to be 63.43%, 77.61%, 63.43% and 76.49% respectively. Specificity of RMI-1, 2, 3 and 4 was calculated to be 68.75%, 65.62%, 65.62% and 62.50% respectively. RMI-2 and RMI-4 had maximum sensitivity while RMI-1 had maximum specificity. Overall RMI-2 appears to be the most accurate of all the four RMI. Conclusions: Overall RMI 2 appears to be more accurate of all.it may be concluded that, the RMI is a simple scoring system with higher accuracy in differentiating benign from malignant ovarian masses, it can be easily introduced in clinical practice and can be the test of choice in the preoperative evaluation of the adnexal mass under primary settings. Based on our study, RMI 2 use with ultrasound findings can be a useful and applicable method for initial assessment of patients with pelvic masses.