Introduction: Patients with mixed dyslipidemia are presented with high levels of low-density lipid cholesterol (LDL-C), triglycerides (TG), and reduced high-density lipid cholesterol (HDL-C). Though useful in lowering LDL-C, therapy with rosuvastatin is insufficient in optimizing the overall lipid profile, thus putting the patient at risk of residual cardiovascular risk. A combination of statin with other lipid-modifying agents has been used with more efficient lipid control and cardiovascular risk prevention. Of these, fenofibric acid is the most frequently used, along with rosuvastatin. Methods: Authors conducted a literature search of published literature to assess the use of rosuvastatin and fenofibrate combination in the management of mixed hyperlipidaemia. Results and discussion: The authors selected a total of 46 articles to be included in the review. Due to the small number of articles and heterogeneity on the combination of rosuvastatin and fenofibrate combination in mixed hyperlipidemia, the findings herein are presented using narrative summaries. Based on the thorough assessment of the selected literature, the essential themes that emerged from the review include safety and efficacy of rosuvastatin and fenofibrate combination, place of therapy of rosuvastatin, and fenofibrate combination, and potential cardiovascular risk reduction with rosuvastatin and fenofibrate combination. Conclusion: Based on the review, the authors suggested that the combination therapy with fenofibric acid was beneficial, well-tolerated with a similar safety profile compared with statin monotherapy. The combination therapy of moderate dose rosuvastatin and fenofibric acid led to a reduction of cardiovascular risk factors via several pathways.
Background: Every year millions of older people experience a fall. There are many reasons associated as to why a fall occurs in elderly: musculoskeletal weakness, balance issues etc. A fall can lead to a serious injury or mortality depending on the type and impact of the fall. As the environment for the elderly was restricted to their homes during the Covid-19 pandemic, this study aimed at assessing the characteristics of falls during the pandemic. Materials and methods: 60 elderly individuals aging 60 years and above participated in the study. This included 36.7% males and 63.3% females. A pre-validated questionnaire was used to assess the characteristics of falls. Result: Fear of fall was not experienced or was same as before the lockdown however the fall percentage decreased by 7% during the lockdown. Conclusion: Falls among the elderly decreased during the Covid-19 pandemic lockdown.
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