Background: Hypertensive disorders of pregnancy is reported to cause about 60-80% of maternal deaths. Platelet indices are biomarkers of platelet activation. Among these platelet indices, mean platelet volume (MPV), and platelet distribution width (PDW), platelet large cell ratio (PLCR) is a group of platelet parameters. When platelets are activated, they become larger in size which causes increased platelet indices such as MPV, PDW and PLCR. So, platelet indices can give an idea of platelet activation. A comparative study of coagulation profile and platelet indices at term in pre-eclamptic, eclamptic and normal pregnancy along with fetomaternal outcome.Methods: This study was carried out in department of obstetrics and gynaecology in collaboration with department of pathology, Rabindranath Tagore Medical College (RNTMC), Udaipur. Cases were selected by systematic random sampling. Bleeding time (BT), clotting time (CT), prothrombin time (PT), mean platelet volume (MPV), platelet distribution width (PDW), and activated partial thromboplastin time (aPTT) to analyse hypertensive disorders in pregnancy (HDP) during the period January 2021 to December 2021.Results: Significant difference was seen in bleeding time (seconds), prothrombin time (seconds), aPTT (seconds) between normal pregnancy as compared to pre-eclampsia and eclampsia. (p value <0.05). Patients’ admission in neonatal intensive care unit (NICU) was significantly higher in eclampsia (p<0.0001) and pre-eclampsia (p<0.0001) as compared to normal pregnancy (66.67%, 43.24% versus 2% respectively).Conclusions: We conclude that coagulation profile like (BT, CT, PT, and aPTT), platelet counts along with platelet indices- MPV, PDW are useful markers, which were significantly raised in patients with preeclampsia and eclampsia. Platelet indices along with coagulation profile emerges as an important, simple, cost effective and effortless tool for predicting severity of pregnancy induced hypertension (PIH).

Background: Second trimester abortion is termination of pregnancy in a period from 13 to 28 weeks of gestation. Second trimester losses may be due to maternal factors such as uterine malformation, growths in the uterus (fibroids), or cervical problems. These conditions also may contribute to premature birth.  Aims and objectives were to compare the efficacy, safety and suitability of combination of misoprostol with intracervical Foley’s catheter v/s misoprostol alone for termination of second trimester pregnancy.Methods: This randomized controlled trial study was conducted on 100 study subjects who passed our inclusion and exclusion criteria. Group A: received misoprostol with intracervical Foley’s catheter. Group B: received misoprostol alone. The groups were compared with respect to the patients’ characteristics, gestational age, indication for termination of pregnancy, rate of complications, etc.Results: Mean value of age (years) of study subjects was 27.12±4.5. Mean induction to delivery time (hours) in P0 was 17.73±6.46 and in P1-P2 was 14.78±4.9 which was significantly higher as compared to ≥P3 (11.46±3.82). (p=0.0004). Mean induction to delivery time (hours) in 14 to 18 weeks was 15.25±5.4 and >18 weeks was 15.02±5.84. (p=0.854). Distribution of side effect between group A and B. (6% vs 20% respectively) (p=0.041).Conclusions: We conclude that intracervical Foley catheter and vaginal misoprostol is a safe and effective method for second trimester abortion as compared to misoprostol alone group with no additional risks.