Background: Metabolic syndrome is a set of metabolic disorders and is considered as a predictor of cardiovascular risks. The expression of several specific genes and the related protein products also show their significance in pathophysiology of Metabolic Syndrome. Secreted Frizzled Related Protein 4 is a product of expression of SFRP4 genes. SFRP4 has been linked with inflammatory responses quite similar to the responses as in metabolic syndrome pathogenesis. Aim: The current study aimed to assess the circulatory level of Secreted Frizzled Related Protein 4 among metabolic syndrome individuals. Method: Estimation of SFRP4 was done by ELISA technique by using Human SFRP4 ELISA kit (Make- Bioassay Technology Laboratory, Cat no- E2327Hu, Zeijhang, China). Results: Mean concentration of serum SFRP4 in Metabolic Syndrome subjects (2.06 ± 1.39 ng/ml) was significantly higher than the mean concentration of healthy controls (1.28 ± 1.29 ng/ml)  (p< 0.05 *). Conclusion: A significant correlation of serum SFRP4 level with Fasting blood glucose and HbA1c seen in the findings of this study puts on an extra contribution to consider this protein as a potential Biomarker for Type II Diabetes Mellitus.

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