BACKGROUND AND AIMSTo study and compare Labetalol and Clonidine as premedication to attenuate haemodynamic changes to Laparoscopy through oral route, as it is safe method of administration and easy to prescribe. METHODSIn a prospective, comparative randomised study, 60 adult patients of both sexes of ASA Grade I and II were divided randomly into 2 groups of 30 each, Group L and Group C. Group L were given Tab. Labetalol 200mg orally 60-90 minutes before induction. Group C were given Tab. Clonidine 300µg orally 60-90 minutes before induction. We compared the degree of attenuation of haemodynamic changes during laparoscopic surgeries. RESULTSOral Clonidine has better control on the rise in heart rate and mean arterial pressure (MAP) during laryngoscopy for laparoscopy compared to oral Labetalol. CONCLUSIONWe conclude that oral Clonidine showed better attenuation of haemodynamic changes than oral Labetalol.