Background: Ischemic injury to the brain caused by a sudden drop in blood supply causes over 80% of strokes. Large artery blockage occurs in about 25-35 percent of strokes, and patients in this category often have severe neurological impairments. The prognosis is bleak if treatment is not started right away. Imaging of the brain after a stroke is crucial for determining the extent of tissue damage and guiding treatment. Aim: To determine the effect of early hand rehabilitation post ischemic stroke. Presentation of Case: A 35-year-old woman with a history of hypertension acquired aphasia, left hemiplegia, and hemisensory loss all at the same time. She was sent to the hospital's emergency room. On CT the blockage of the right middle cerebral artery revealed an acute ischemic stroke. The Motor Assessment Scale is taken in which there is a hand function domain also to assess it. Discussion: There are many studies on hand rehabilitation, but usually we stated hand rehabilitation late. Our primary focus during rehabilitation is upper limb and lower limb, hand is a little neglected part. So, in this case study we will be focusing on early had rehabilitation. Conclusion: The case data confirms a diagnosis and appropriately planned physical rehabilitation care that resulted in a progressive improvement on STREAM Score, Motor Assessment Scale Score, Barthal index score and WHO-QOL score.