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Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) with analgesic and antipyretic properties. Famotidine is a competitive histamine H2-receptor antagonist, is used to treat gastrointestinal disorders such as gastric or duodenal ulcer. The aim of the present research work was to develop accurate and rapid Area under Curve Method to determine Ibuprofen and Famotidine in combined dosage form. The Area under Curve method, wavelength range selected are 259-269 nm for Ibuprofen and 282-292 nm for Famotidine respectively. The developed method was obeyed the Beer's law and was found linearity range between 80-640 μg/ml for IBU and 2-22 μg/ml for Famotidine; while the correlation coefficient were 0.9985 for Ibuprofen and 0.9982 for Famotidine. Parameters such as linearity, accuracy, precision, LOD and LOQ values were used for validation of the methods as per ICH guidelines for both methods. Intra and inter-day precision %RSD values were less than 2%. This method is found suitable for day to day analysis of Ibuprofen and Famotidine in combined dosage form.

Geraniol (GE), an acyclic monoterpene, is a chief constituent of essential oils of herbs and fruits. It possesses diverse pharmacological actions like antioxidant, anti‐inflammatory, anti‐apoptotic, and anti‐parkinson. However, its neuroprotective potential in stroke is yet to be explored at large. The present study evaluated the neuroprotective potential of GE against the global model of cerebral ischemia/reperfusion (I/R)‐injury in rats. Bilateral common carotid artery (BCCA) occlusion for 30 min followed by 7 days of reperfusion caused varied biochemical/enzymatic alterations viz. increase in levels of lipid peroxidation (LPO), nitric oxide (NO), xanthine oxidase (XO), and decrease in the levels of cerebroprotectives like superoxide dismutase (SOD), catalase (CAT), total thiols, and glutathione (GSH). GE‐pretreatment markedly reversed these changes and restored the levels of protective enzymatic and non‐enzymatic antioxidants near to normal compared to I/R group. Besides, GE treatment showed marked improvement in anxiety‐related behavior and neuronal deficits in animals subjected to I/R injury. Moreover, 2,3,5‐triphenyl tetrazolium chloride (TTC)‐stained rat brain coronal sections and histopathological studies revealed neuronal protection against I/R‐injury, as evidenced by a reduction in infarct area (%) and an increase in hippocampal CA1 neuronal density in the GE‐treated groups. The results of this study revealed that GE exhibited potential neuroprotective activity by reducing oxidative stress and infarction area, and protecting hippocampal CA1 neurons against I/R‐injury in the global stroke model in rats.

Monoterpenoids, being a valuable component of essential oils, constitute important groups of natural compounds. They contain two isoprenoid units in their structure. Monoterpenoids are the secondary metabolites of the plants and they do not exert primary function in the plants. Owing to their higher abundance in the plant kingdom, they find wide application in the perfumery industry, food, and health care products for human beings. Monoterpenoids either in direct form or modified form exert diverse pharmacological effects. The present review reports wide pharmacological activities of monoterpenoids like learning and memory enhancer, antidepressant, anxiolytic, antinociceptive, anticonvulsant, and neuroprotective indicating the promising potential of monoterpenoids to treat a wide range of complex diseases.