SARS-CoV-2, a newly emerged pathogen in December 2019, marked as one of the highly pathogenic Coronavirus, and altogether this is the third coronavirus attack that crossed the species barrier. As of 1 st July 2020, it is spreading around 216 countries, areas or territories, and a total of 10,185,374 and 503,862 confirmed cases and death reports, respectively. The SARS-CoV-2 virus entered into the target cells by binding with the hACE2 receptors. Spike glycoprotein promotes the entry of the virus into host target cells. Literature reported a significant mutation in receptor binding sites and membrane proteins of the previous SARS-CoV to turned as SARS-CoV-2 virus, responsible for most dreadful pandemic COVID-19. These modifications may be the probable reason for the extreme transmission and pathogenicity of the virus. A hasty spread of COVID-19 throughout the world is highly threatening, but still, scientists do not have a proper therapeutic measure to fight with it. Scientists are endeavoring across the world to find effective therapy to combat COVID 19. Several drugs such as Remdesivir, Hydroxychloroquine, Chloroquine, Ribavirin, Ritonavir, Lopinavir, Favipiravir, Interferons, Bevacizumab, Azithromycin, etc. are currently under clinical trials. Vaccine development from various pharmaceutical companies and research institutes is under progress, and more than ten vaccine candidates are in the various phases of clinical trials. This review work highlighted the origin, emergence, structural features, pathogenesis, and clinical features of COVID-19. We have also discussed the in-line treatment strategies, preventive measures, and vaccines to combat the emergence of COVID-19.

Objectives The study examined the predictive strengths of self‐esteem, and positive and negative self‐compassion for hedonic and eudaimonic well‐being as well as assessed the relative mediating roles of positive and negative self‐compassion for the relationships among self‐esteem, and hedonic and eudaimonic well‐being. Design A correlational design was employed through which self‐esteem, self‐compassion, and hedonic and eudaimonic well‐being were measured. Methods One hundred thirty‐four male (M = 25.11, SD = 1.66) and 138 female (M = 21.89, SD = 1.87) participants were chosen by a convenient sampling. Results The findings evinced that there were significant positive correlations among self‐esteem, positive self‐compassion, and hedonic and eudaimonic well‐being while negative self‐compassion exhibited small positive correlations with both the well‐being measures (criterion). The regression analyses showed that self‐esteem and positive self‐compassion reflected significant predictive strengths for hedonic as well as eudaimonic well‐being while negative self‐compassion did not. This was also true for the social and psychological aspects of well‐being. The β values reflected that positive self‐compassion did show a higher contribution for both the well‐being measures as compared to self‐esteem. Conclusions The findings evinced that positive, not negative, self‐compassion mediated the relationship between self‐esteem and hedonic well‐being as well as self‐esteem and eudaimonic well‐being. Moreover, self‐esteem and self‐compassion have predictive strengths for both kinds of well‐being. The findings showed the relevance of self‐esteem and self‐compassion to underscore well‐being. The implications and directions for future researchers have been discussed. Practitioner points Contrary to the earlier findings suggesting self‐esteem and self‐compassion carrying relevance to explicate performance and well‐being of people with individualistic and collectivistic cultures, respectively, the findings of this study suggest both the constructs to be useful to understand the well‐being of people with both the values belonging especially to the fast‐changing societies like India. The study also suggests reconceptualization and empirical verification of self‐compassion that will make it more effective for enhancing and promoting interventions for positive life outcomes.

Background: India first detected SARS-CoV-2, causal agent of COVID-19 in late January 2020, imported from Wuhan, China. From March 2020 onwards, the importation of cases from countries in the rest of the world followed by seeding of local transmission triggered further outbreaks in India. Methods: We used ARTIC protocol-based tiling amplicon sequencing of SARS-CoV-2 (n=104) from different states of India using a combination of MinION and MinIT sequencing from Oxford Nanopore Technology to understand how introduction and local transmission occurred. Results: The analyses revealed multiple introductions of SARS-CoV-2 genomes, including the A2a cluster from Europe and the USA, A3 cluster from Middle East and A4 cluster (haplotype redefined) from Southeast Asia (Indonesia, Thailand and Malaysia) and Central Asia (Kyrgyzstan). The local transmission and persistence of genomes A4, A2a and A3 was also observed in the studied locations. The most prevalent genomes with patterns of variance (confined in a cluster) remain unclassified, and are here proposed as A4-clade based on its divergence within the A cluster. Conclusions: The viral haplotypes may link their persistence to geo-climatic conditions and host response. Multipronged strategies including molecular surveillance based on real-time viral genomic data is of paramount importance for a timely management of the pandemic.

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