Pharmaceutical excipients are important chemical constituents of medications to overcome challenges such as solubility, stability and bioavailability of the active pharmaceutical ingredient (API). They also play a critical role in formulating, assuring the quality and patient acceptability of the medicine. [1][2][3][4] The strategy for the selection of excipients is a complicated task in pediatric medicine development. It requires various considerations such as acceptable taste, age, dosage forms, among others to be accounted for in order to select safe excipients. 5 Concerns

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Novel derivates of 3‐[1‐(pyridin‐2‐ylimino)‐ethyl]‐benzopyran‐2‐ones 3(a–c) and 3‐[1‐(pyrimidin‐2‐ylimino)‐ethyl]‐benzopyran‐2‐ones 3(d–e) are synthesized by condensation reactions of 3‐acetyl‐benzopyiran‐2‐one 2 with corresponding heterocyclic amines 2(a–e). These products are synthesized by catalytic reactions using zinc chloride, in reflux conditions. Products are characterized on the basis of their spectroscopic data. Antimicrobial activity of products 4(a–e) against S. aureus, E. coli and Candida albicans are investigated measuring inhibition zones around disks marked previously with corresponding compounds. Results are shown for a considerable activity of products against these microorganisms