Background: Enteric fever is a major public health problem in developing countries like India. It affects all age groups but young children are at highest risk. Timely management with appropriate antimicrobial therapy can reduce both morbidity and mortality. In recent years, the emergence of antimicrobial resistance is a significant challenge. Therefore, this study was undertaken to study antibiotic sensitivity pattern of the Salmonella isolates. Aims and Objectives: The aims of this study were to estimate the prevalence of resistance to commonly used antibiotics in the Salmonella isolates. Materials and Methods: Children between 6 months and 14 years of age admitted for fever and whose blood culture was positive for Salmonella Typhi or Salmonella Paratyphi A, B, or C were included in the study over a period of 2 years (August 2018–July 2020). Results: There were 155 patients of enteric fever whose blood culture results were positive for S. Typhi/S. Paratyphi who were included in the study. Out of the 155 culture positive cases, S. Typhi was isolated in 135 (87.1%), S. Paratyphi A in 16 (10.3%) and S. Paratyphi B in 4 (2.6%) cases. All the 135 isolates of S. Typhi were sensitive to cephalosporins. High rate of sensitivity was noted for the first-line drugs – amoxicillin, ampicillin, and trimethoprim-sulfamethoxazole. All 16 isolates of S. Paratyphi A were sensitive to cephalosporins. All the isolates of S. Paratyphi B tested were sensitive to cephalosporins, azithromycin, nalidixic acid, and trimethoprim-sulfamethoxazole. Conclusion: At present, there is low prevalence of resistance to first-line drugs and third-generation cephalosporins and high resistance to fluoroquinolones, nalidixic acid, and azithromycin as noted in this region. Rational antibiotic selection should be based on sensitivity pattern to prevent emergence of resistant strains.

Background: Dehydration fever is one of the most common non-infectious causes of fever in newborns. It can be very dangerous and can lead to serious complications and even death. Early recognition of dehydration fever by serial monitoring of weight to detect inappropriate weight loss and early correction of dehydration fever can prevent disastrous complications in the baby. Aims and Objectives: The aim was to study the incidence and clinical profile of dehydration fever in exclusively breastfed neonates admitted at tertiary care hospital. The primary objective is to know the incidence of dehydration fever in exclusively breastfed neonates. Secondary objectives are to study the clinical and laboratory profile of dehydration fever and to study the management and outcome of dehydration fever in terms of morbidity and mortality. Materials and Methods: The study was conducted in the Department of Pediatrics of a tertiary care hospital in Ahmedabad, Gujarat. Neonates between 0 and 28 days of life born at full term (37–40 weeks of gestation), on exclusive breastfeeding and having an axillary temperature of >37.5°C/100.4°F and clinical signs of dehydration were included in the study. Clinical and laboratory profile of neonates with dehydration fever was noted. Results: The incidence of dehydration fever was 4.71/100 neonates (152 out of 3225 neonatal admissions). Maximum cases were noted in May. The most common predisposing factor was primiparity (n = 119 [78.28%]), followed by the poor establishment of breastfeeding (n = 117 [76.97%]) and cesarean section delivery (n = 97 [63.81%]). Among 152 neonates with dehydration fever, 118 neonates (77.64%) had hypernatremic dehydration and 34 (22.36%) had isonatremic dehydration. All the neonates with dehydration fever were successfully treated. No deaths were observed in the present study. Conclusions: Dehydration fever is an important cause of neonatal fever in tropical countries like India, especially during the summer months. The present study highlights the need to be vigilant about dehydration, hypernatremia, and hyperbilirubinemia in breastfed neonates while emphasizing the need to promote exclusive breastfeeding. Dehydration fever can be prevented by educating mothers regarding breastfeeding techniques, beginning in the antenatal period. Those with identifiable problems should be referred promptly for lactation management and supportive counseling.