11 C]FMZ PET datasets and arterial plasma input functions were available for 15 patients with medically refractory medial temporal lobe epilepsy (TLE) and histologically verified unilateral HS and for 13 control subjects. SPM2 was used for analysis. ADD1020 and ADD2040 images showed decreased FMZ uptake ipsilateral to the epileptogenic hippocampus in 13/15 cases; 6/13 had bilateral decreases in the ADD1020 analysis and 5/13 in the ADD2040 analysis. BP-SRTM images detected ipsilateral decreases in 12/15 cases, with bilateral decreases in three. In contrast, VD images showed ipsilateral hippocampal decreases in all 15 patients, with bilateral decreases in three patients. Bilateral decreases in the ADD images tended to be more symmetrical and in one case were more marked contralaterally. Full quantification with an image-independent input should ideally be used in the evaluation of FMZ PET; at least in TLE, intrasubject correlations do not predict equivalent clinical usefulness.

The prone position is associated with uncommon but well recognised complications which can lead to significant morbidity. Facial pressure ulcers are one of these rare complications, causing understandable distress due to the conspicuous nature of the injury. Risk factors include the duration of the procedure, age, obesity, and the use of steroids [1]. The type of face-cushion [2] and alternatives to a face-cushion [3] have also been shown to affect the incidence of facial pressure sores.We present a case of a 79-year-old gentleman with no significant previous medical history who developed facial pressure sores following an uncomplicated 4 hour procedure in the prone position, using an "Absolute Face Support Cushion" supplied by Medical Devices Ltd [Portland Street, Southport, Merseyside]. More than 200,000 procedures have been performed with this face-cushion, including a number of cases lasting 10-17 hours, with no similar complication reported.

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