Introduction. Haemorrhoids and anal fissures are considered as the most common anorectal conditions. Aim. To evaluate the safety and efficacy of Pilex Forte tablets in combination with Pilex Ointment as compared to the Standard of Care in common anorectal conditions Material and methods. Randomized, open-label, controlled comparative clinical study conducted on 162 patients of either sex, aged between 18-50 years, confirmed with common anorectal conditions. As per randomization, patients received either standard of care or Pilex Forte tablet along with Pilex Ointment at a recommended dose of two tablets twice daily and twice daily local application (anal) for a period of 4 weeks. Clinical safety and efficacy assessments were carried out at study specific scheduled visits. Laboratory assessments were carried out only at screening and at the end of the study. Results. Patients who completed the study were considered for statistical analysis. Significant clinical improvement was observed in patients with anorectal conditions who received Pilex Forte tablet and Pilex Ointment than to those who received standards of care. No abnormal lab values were recorded and there were no adverse events reported during the study period. Conclusion. Pilex Forte tablet along with Pilex Ointment at recommended dose is safe and effective in the management of anorectal conditions like haemorrhoids and fissure-in-ano.

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Bitumen typically performs the function of a binder due to its adhesive properties and the ability to assume liquid form when heated and solid form when cooled. The softening of pavement bitumen during summer temperatures causes rutting on roads and its winter fragility leads to low-temperature cracking. In order to address these issues, a variety of additives have been proposed over the years as modifiers to improve the performance of bituminous concrete. In this direction, the aim of the present work was to establish the efficacy of the chemical additives, namely, titanium dioxide and carbon black in bitumen. To accomplish this objective, plain bitumen and modified bitumen samples with different percentages of titanium dioxide and carbon black were prepared and tested for various rheological properties. The study also examined the viscoelastic behaviour of the samples using dynamic shear rheometer. The findings of this study demonstrated that titanium dioxide and carbon black in bitumen are strong viscosity enhancers. Also, the modified bitumen specimen yielded in high phase angle indicating high viscous behavior and higher resistance to rutting and fatigue. The research findings also suggested that titanium dioxide and carbon black aid in the preparation of durable and sustainable mixtures for flexible pavements.

Background: Lymph node metastasis is the most important factor in the prognosis of oral cancers and survival drops by 50% in the presence of malignant lymph nodes. Most of the lymph node enlargement in oral cancers is due to tumor-associated inflammation rather than metastasis. The aim and objectives of the study was to assess the enlarged reactive and positive cervical lymph nodes clinically and radiologically with the histopathology of neck nodes. Methods: All the oral cancer patients were examined clinically for enlarged neck nodes and subjected to contrastenhanced computed tomography (CECT) oral cavity and neck. In CECT, all the characteristics of nodes were recorded, and after neck dissection, all levels of lymph nodes were assessed histopathologically. Results: In our study, 24 patients were included; among them, 31 enlarged lymph nodes were seen clinically. CECT showed a total of 90 enlarged lymph nodes which includes 21 positive nodes. In histopathology 538 lymph nodes were isolated, and among them, only 32 lymph nodes were found to be positive for malignancy. Conclusions: The detection rate of enlarged lymph nodes is more with histopathology than radiological and clinical examination. In our study, 94% of lymph node enlargement was proven to be reactive, which shows more tumorassociated inflammation.