Background: The characterization of intensive care unit (ICU) admitted COVID-19 patients with co-morbid conditions requiring ventilator support can help investigators worldwide to prepare for emergency situation arising at the time of spread of disease. The objective of our study is to analyse the outcome of ICU admitted COVID-19 patients with co-morbid conditions. Methods: Post ethics committee approval for multiple centers, data of 212 consecutive discharged and death COVID-19 confirmed ICU patients were included and analyzed. These patients of all age groups and genders were admitted in Bhaktivedanta Hospital and Research Institute, Mira Road, Mumbai, Maharashtra, India which is a dedicated COVID hospital from March 2020 to November 2020. Results: Of the total 212 ICU patients, 17 (9%) cases were moderate, 195 (91%) were severe cases as per CT severity score grading, median duration of stay in the hospital was 9 (37%) days. Diabetes mellitus was the leading co-morbid condition with frequency of 27.8% followed by ischemic heart disease (IHD) (5.6%), chronic kidney disease (CKD) (5.1%), asthma (3.77%) and chronic obstructive pulmonary disorder (COPD) (0.94%). Conclusions: Not all patients with co-morbid conditions progress towards poor lung function. IHD is the worst prognostic indicator for progressing towards poor lung function as compared to diabetes, CKD and COPD.