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Multinodular goitre may be treated by subtotal thyroidectomy or total thyroidectomy depending on the factors like symptomology. Objectives:To compare the efficacy and morbidity of total thyroidectomy and subtotal thyroidectomy.Methods: Prospective study done in GMKMCH from June 2012 to June 2014.Results: Based on symptomology decision to do either a subtotal or total thyroidectomy were performed, in compressive symptoms in MNG involving both lobes total thyroidectomy was preferred especially in endemic goitre, subtotal done in MNG without compressive symptoms. No permanent recurrent laryngeal nerve palsy noted in both groups. But transient hypoparathyroidism occur in both groups Conclusion: Total thyroidectomy is a safe choice for the benign MNG disease with euthyroid state and it provide a radical but definitive control of disease without risk of recurrence. In experienced hand total thyroidectomy assures total relief of compressive symptom and comparable low incidence of major complications.