Ayurveda is classified into 8 branches Agadtantra is one of important branch of Astanga ayurved which deals with study of poisons origin their properties harmful effects fatal doses their management prevention of poisoning method of detection and estimation of poison. Poisons may be from herbs, mineral or animal origin. In modern science parallel branch known as Toxicology. Today the scope of toxicology continues to grow rapidly and the subject is to profound importance to human and animal life too. Evaluation of residues of pesticides on Cauliflower (Brassica oleracea) before and after Dhavana by Vishaghna Dravya Shirish (Albizzia Lebbek). Cauliflower (Brassica oleracea) and Shirish panchanga (Albizzia Lebbek). Identification and authentication was done in department of Dravyaguna. The percentage of Cypermethrin residue was found to be decreased more by shirish kwatha(73.86% ) than hot water(67.33) and tap water(51.56%). The percentage of Chlorpyrifos residue was found to be decreased more by shirish kwatha(48.83%) than hot water(42.93%) and tap water(35.71%). The percentage of Imidaclopride residue was found to be decreased by tap water(86.54%) than that of hot water(72.44%) and shirish kwatha (78.84%).Dhavana with shirish kwatha was found more efficient method for reduction of pesticidal residue in cauliflower.