Wnt/β-Catenin signaling pathway plays a major role in embryonic development and tumorogenesis on several human cancers. In colorectal cancer, the frequent mutations of Adenomatous polyposis coli (APC), β-Catenin and Glycogen synthase kinase 3β (GSK-3β) leads to accumulate the unphosphorylated β-catenin in cytoplasm. Further, its translocate into the nucleus, where it interacted with T-cell factor/ Lymphocyte enhancer factor (TCF/LEF) family of transcription factors to activate inappropriate expression of downstream targets. Therefore, Wnt/β-Catenin signaling proteins are mainly focused as potential therapeutic targets on colorectal cancer. In recent investigations, the antitumorogenic and chemopreventive property of phytochemicals extracted from the flowers of Butea monosperma (Bm) has been elucidated by using transgenic and rodent animal models. In the present study, the eight major compounds of n-butanol fractions of Bm flowers were docked against Wnt/β-Catenin signaling proteins by using AutoDock tool v 4.2 and ADT v1.5.4. The incurred active compounds of butrin and isobutrin showed a good binding interaction with Wnt/β-Catenin proteins. Hence, this finding suggesting that butrin and isobutrin would be considered as a potent antitumorogenic drug to target Wnt/β-Catenin associated cancers.