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ABSTRAKPenelitian ini bertujuan untuk mengetahui granul effervescent ekstrak daun binahong yang diformulasikan telah memenuhi persyaratan dan menentukan formulasi granul effervescent yang terbaik. Penelitian ini merupakan penelitian deskriptif eksperimental dengan pengambilan data dari evaluasi granul effervescent. Untuk membuat sediaan granul effervescent terlebih dahulu dilakukan ekstraksi daun binahong. Ekstrak diperoleh dari metode maserasi menggunakan pelarut etanol 70%. Formula granul effervescent dibuat sebanyak tiga buah dengan variasi konsentrasi ekstrak F1 7,4%; F2 14,8%; dan F3 22,2%. Granul effervescent daun binahong dibuat dengan menggunakan metode granulasi basah dan dilakukan evaluasi mutu fisik granul meliputi uji organoleptik, kadar air, volume tuang, volume guncang, daya alir, waktu dispersi, dan pH. Hasil penelitian menunjukkan semua granul effervescent ekstrak daun binahong (Anredera cordifolia (Tenore) Steen.) telah memenuhi persyaratan granul yang baik. Dari ketiga formulasi, granul terbaik adalah F3, di mana memiliki nilai terbaik pada pengujian kadar air, uji volume guncang, daya alir, dan pH. ABSTRACTThe purpose of this research are to find out whether the formulation of effervescent granules from binahong leaves extract has met the standards for effervescent granules and determine the best formulation of effervescent granules. This research is descriptive experimental with data collection from evaluation of effervescent granules. To be able to make effervescent granules, extraction of binahong leaves must be made first. The extracts resulted from a maseration method with 70% ethanol. The effervescent granules formulation were made by 3 design based on their concentration F1 7.4%; F2 14.8%; and F3 22.2%. Effervescent granules of binahong leaves extract are prepared by using wet granulation method. Several physical tests were carried out on the results of effervescent granules of binahong leaves, including organoleptic test, moisture content test, pour volume test, volume of shringkage test, flow capacity test, dispersion test, and pH. The test results showed that all the effervescent granules of binahong leaves (Anredera cordifolia (Tenore) Steen.) have met the standard requirements as good granules. The third formula became the best formulation, With the best value in moisture content test, volume of shringkage test, flow capacity test, and pH.

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The increasing of online coronavirus disease-2019 (COVID-19) information-sharing in digital media can contribute to the emergence of misinformation in public. Much insufficient knowledge will confuse public understanding and affect their quality of life. The study purposed to assess the knowledge and its influence on Indonesian students' quality of life during the COVID-19 crisis. A cross-sectional study was conducted between October and December 2020 by distributing online questionnaires. The data analysis was run through the Spearman correlation method by using SPSS version 21.0. A total of 200 respondents aged over 17 years were recruited using a snowball sampling technique. Most study respondents had insufficient knowledge about COVID-19, 23% of them had moderate knowledge, and only 17.5% had high knowledge. They obtained primary sources of COVID-19 information from social media platforms. The results showed that health science students have a better understanding than social science students (ρ<em>&lt;</em>0.001). The level of knowledge has a significant associated with psychological domain (ρ=0.020), environmental domain (ρ=0.046), and overall quality of life (ρ=0.047). Thus, the media control center is vital to encounter valid information in providing better knowledge and quality of life during a pandemic.