The corrosion resistance of SS 316L alloy in artificial saliva, in the absence and presence of Amlodiphine-2.5 mg has been evaluated by polarization study and AC impedance spectra. Polarisation study reveals that in the presence of Amlodipine-2.5 mg, LPR value increases and corrosion current decreases. In presence of Amlodipine-2.5 mg mg, the corrosion resistance of SS 316L alloy in artificial saliva increases. AC impedance study reveals that in the presence of Amlodipine-2.5 mg, R t value increases and C dl decreases. In the presence of Amlodipine-2.5 mg the corrosion resistance of SS 316L alloy in AS increases. From the present study it is concluded that people clipped with orthodontic wire made of SS 316L alloy need not hesitate to take Amlodipine-2.5 mg orally.