Background: Heart surgery (HS) complications such as renal damage (RD), which is a frequent and major consequence, are linked to higher mortality and morbidity rates as well as a significant financial burden. Several different pathophysiological ideas might explain the multifaceted complexity of the HS-RD pathogenesis. Aim: The purpose of this research is to identify RD after HS and to evaluate the results of diagnostic criteria, pathogenesis, and preventative measures. Methods: This retrospective analysis of HS patients examined the occurrence and impact of several definitions of RD, Renal Damage Network (RDN), and Kidney Disease: Improving Global Outcomes (KDIGO) or risk, injury, failure, loss, and end-stage kidney disease (RIFLE). We also defined transient RD and sustained RD. Results: RIFLE-Risk had the greatest positive probability ratio of every definition, continued with sustained RD (positive likelihood ratio = 2.27) for the best definition. 39 patients with KDIGO RD and all 80 patients having late RD were excluded from the RD defined by RDN criteria. Conclusion: The pathogenesis, definition, diagnosis, and preventative measures of RD in HS patients are discussed in this article. Based on the capacity to forecast short-term mortality, the risk was shown to be the most accurate definition of RD, followed by injury, failure, loss, and end-stage RD.