According to the results, it has been thought that active MMP-9 shows a certain degree of atherosclerotic changes on blood vessels better than total MMP-9. MMP-9, active one, could present an early marker of atherosclerosis, especially on coronary blood vessels, in diabetics with type 2.

The Influence of Type And Duration of Cardiovascular Complications On Antioxidative Parameter Values In Type 2 Diabetic Patients It is well established that type 2 diabetes mellitus is associated with highly increased risk of coronary heart disease, cardiovascular disease (CVD), and total mortality. CVD is the leading cause of death of people with diabetes. The aim of our study was to test the effect of type and duration of cardiovascular complications on antioxidant parameter values: superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione reductase (GR) and total antioxidant status in patients with type 2 diabetes mellitus and manifested cardiovascular complications. Out of 100 subjects included in the study, 69 subjects were type 2 diabetic patients with cardiovascular complications and 31 age-matched controls. Statistical data processing revealed significantly lower antioxidant defense (p<0.001) in patients with type 2 diabetes and cardiovascular complications manifested as coronary artery disease (CAD), hypertension (HTA) and myocardial infarction experienced in the previous 8 years (AMI). The type 2 diabetics with longer history of diabetes and coronary artery disease had higher fasting glucose values, higher GR activity, but lower TAS and SOD activity (p<0.05). Fasting glucose levels were in negative correlation with SOD and GPx activities in the subgroups of diabetics with severe cardiovascular complications (CAD+AMI, CAD+AMI+ HTA) (p<0.05).

Literature data on the association between the incidence of ruptured abdominal aorta and seasons are contradictory. The influence of climatic factors on the rupture of abdominal aorta is geographically dependent.The aim of this research was the investigation of the connection between the incidence of ruptured abdominal aorta and seasons at the territory of the southern Serbia.In this retrospective study, 59 consecutive patients, who were hospitalized in the Vascular Surgery Clinic, Clinical Center Niš, between 2008 and 2011, were involved, having the rupture of the infrarenal segment of the abdominal aorta. The incidence of the ruptured aneurysm of the abdominal aorta was analyzed with regard to calendar years, seasons and months.There was no significant connection between calendar year (χ 2 test=3,836, p=0,28), seasons (χ 2 test=3,4, p=0,334) and months (χ 2 test =11,109, p=0,434) and the incidence of the disease.According to the results of this study, it can be concluded that the incidence of ruptured abdominal aortic aneurysm in the southern Serbia is not related to seasons and months during the year.

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