As COVID-19 pandemic has caused unprecedented human health consequences. Knowledge, attitude, perception of general population of India towards the transmission and prevention plays vital role for effective control measures. The study was conducted to assess the knowledge, attitude and practice of the general public of India on COVID-19. In this study, a web-based cross-sectional survey was conducted between 10 th March to 18 th April 2020. A 19-item questionnaire was generated, Cronbach's alpha was used to measure the internal consistency of the questionnaire & randomly distributed among the public using Google forms through social media networks. The chi-square test or Fischer exact test was used to compare categorical data and multiple linear regression was used to identify factor influencing KAP. Among 7978 participants, the overall knowledge, attitude and practice score was 80.64%, 97.33% and 93.8% consecutively. Majority of Indian population demonstrated preceded good knowledge, positive attitude and good practice regarding COVID-19 pandemic.

Background: This study aimed to investigate the long-term effects of branched-chain amino acids (BCAAs) supplementations on the parameters associated with improved prognosis in sarcopenic patients with liver cirrhosis (LC) and evaluate its impact on cirrhotic-related events.Methods: A 24-week, single-center, randomized, open-label, controlled, two cohort parallel-group intervention study was carried out by comparing the efficacy of BCAAs against lactoalbumin (L-ALB) on 106 sarcopenic patients with LC. The BCAA (intervention) group was treated with 7.2 g BCAA per dose, whereas the L-ALB group was treated with 6.3 g of L-ALB. The primary outcome was to assess the effect of BCAA on the parameters of sarcopenia, such as muscle mass, muscle strength, and physical performance. The secondary outcomes were to study the combined survival and maintenance of liver function changes in laboratory and prognostic markers over the duration of 6 months.Results: The treatment with BCAA leads to the significant improvement in sarcopenic parameters, such as muscle strength, muscle function, and muscle mass. The total cirrhotic-related complications and cumulative event-free survival occurred fewer in the BCAA group than in the L-ALB group. In addition, prognostic markers improved significantly in the study.Conclusion: The current study demonstrated that long-term BCAAs supplementation improved sarcopenia and prognostic markers in patients with advanced LC.

No abstract

Introduction The correlation among treatment satisfaction with demographic characteristics, health symptoms or psychological health, and quality of life with the prophylactic regime against COVID-19 is rather unexplored. This real-world exploratory study was conducted to determine patient-perspectives regarding their treatment satisfaction receiving Divya-Swasari-Coronil-Kit with correlative impacts on psychological health (PH) and Quality of life (QoL) based on four hypotheses each relating to PH, QoL, Demographic characteristics, and Treatment satisfaction. Methods This cross-sectional, web-based survey collected data on demographic characteristics and psychological health with DASS-21; QoL with 5-level 5-dimension EuroQol instrument; and treatment satisfaction using Treatment Satisfaction Questionnaire for Medication (TSQM) V9. Pearson correlation coefficient analysis was used to examine the relation between TSQM and PH and the demographic variables. Factor analysis was used for multi-collinearity tests, and multiple linear regression analysis was used to explore demographic variables and TSQM. Results Out of 421 initial screenings, 367 patient-participants were included in the analysis. The mean age of included participants was 33.61 ± 9.47 years. Marital status and socio-economic class positively correlated with TSQM. Physical symptoms in patients are positively correlated with depression, anxiety, and stress; and in contrast, negatively with QoL. Global satisfaction with Divya-Swasari-Coronil-Kit medication negatively correlated with depression, anxiety, stress, effectiveness, convenience; whereas global satisfaction correlated positively with QoL. Conclusion Present study (SATISFACTION COVID) indicates that treatment satisfaction due to avaliablity and treatment of Divya-Swasari-Coronil-Kit has constructive and beneficial implications on psychological health, Quality of life and demographic factors. In addition, web-based patient-reported perspectives may well be a feasible way to provide better insights into treatment satisfaction, in relation to psychological health and Quality of life.

Objective: As there is a dearth of researches targeting the Indian population on this issue, we decided to conduct a survey to assess the psychological impact of COVID-19 on mental health and quality of life of Indians. Methods: In this Cross-Sectional study, a total of 2245 participants above 16 y of age were included. Mental health variables were assessed via depression, anxiety and stress subscale (DASS-21), Insomnia Severity Index (ISI-7), Patient health questionnaire (PHQ-15), Quality of life (QoL-5) and social media exposure. Results: The multivariate logistic regression demonstrated female (OR-1.17, 95% CI: 0.99 to 1.38) had significantly higher depression scores whereas, housewife had higher depression (OR-1.68, 95% CI: 1.33 to 2.13), anxiety (OR-1.64, 95% CI: 1.15 to 2.35), insomnia (OR-1.32, 95% CI: 1.14 to 1.53), somatic symptoms (OR-1.76, 95% CI: 1.21 to 2.57). Front line workers had a higher psychological impact with increased scores of anxieties (OR-1.23, 95% CI: 0.79 to 1.53), stress (OR-1.82, 95% CI: 0.76 to 2.55), insomnia (OR-1.65, 95% CI: 1.31 to 2.09). Lower education level had significantly higher score in depression (OR-1.14, 95% CI: 0.73 to 1.32), insomnia (OR-2.42, 95% CI: 2.07 to 2.84), somatic symptoms (OR-2.59, 95% CI: 1.80 to 3.37). Poor physical health, social media exposure was significantly associated with heightened anxiety score. Conclusion: There is a need for psychological intervention as the dynamics and severity of COVID-19 is rapidly changing. These findings could guide the public health authorities to target and implement health measures to combat the pandemic.