Metal complexes are the effective therapeutic compound and it became more emerging field in the drug discovery and delivery. A novel ligand phenyl-glycine -o- carboxylic acid was synthesized and further complexed with the metal (II) chlorides. The synthesized metal complexes was interpreted by FT-IR spectroscopy, Ultra Violet- visible, 1H-NMR, molar conductance, magnetic susceptibility and thermogravimetric study. The electrochemical properties of the ligand and its complexes were inquired in DMF. Antibacterial and fungal activities of the phenyl-glycine -o- carboxylic acid (ligand) and metal complexes were analyzed by three fungal and four bacteria pathogens. The ligand has no activity against Aspergillus terreus, but nickel, copper and cobalt chloride complexes showed good activity against Aspergillus terreus. On anti-bacterial activity compare to ligands and other metal (II) complexes the cobalt (II) complex revealed greater inhibition effect on selected bacteria.

The metal (II) complexes of picolinic acid are prepared in non- aqueous medium and its complexes are characterized by spectral studies (Infra-red spectroscopy, UV-Visible spectroscopy, 1H-NMR spectroscopy and ESR spectroscopy), conductance, magnetic susceptibility and thermal analysis. On heating, the complexes decompose at temperature above 260C. It revealed that all the complexes were stable. The FT-IR evidenced the C=O, C=N, O-H, C=C, and M-O functionalities of all the metal complexes along with corresponding ligands. Thermogravimetric study showed that there is no water molecule in the complexes. The electrochemical behavior of all metal complexes was investigated. From the electronic spectra the geometries of cobalt, nickel and copper is found to be Octahedral, Octahedral, and Distorted octahedral respectively. The complexes of the ligand are evaluated for anti-microbial activity hostile to fungal and bacterial strains. The nickel (II) complex reveals excellent inhibition again the selected four bacterial strains compare with other complexes.