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A hybrid segmentation algorithm is proposed is this paper to extract the blood vesselsfrom the fundus image of retina. Fundus camera captures the posterior surface of the eye and thecaptured images are used to diagnose diseases, like Diabetic Retinopathy, Retinoblastoma, Retinalhaemorrhage, etc. Segmentation or extraction of blood vessels is highly required, since the analysisof vessels is crucial for diagnosis, treatment planning, and execution of clinical outcomes in the fieldof ophthalmology. It is derived from the literature review that no unique segmentation algorithm issuitable for images of different eye-related diseases and the degradation of the vessels differ frompatient to patient. If the blood vessels are extracted from the fundus images, it will make thediagnosis process easier. Hence, this paper aims to frame a hybrid segmentation algorithmexclusively for the extraction of blood vessels from the fundus image. The proposed algorithm ishybridized with morphological operations, bottom hat transform, multi-scale vessel enhancement(MSVE) algorithm, and image fusion. After execution of the proposed segmentation algorithm, thearea-based morphological operator is applied to highlight the blood vessels. To validate theproposed algorithm, the results are compared with the ground truth of the High-Resolution Fundus(HRF) images dataset. Upon comparison, it is inferred that the proposed algorithm segments theblood vessels with more accuracy than the existing algorithms.

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In recent years, skin cancer diagnosis has been aided by the most sophisticated and advanced machine learning algorithms, primarily implemented in the spatial domain. In this research work, we concentrated on two crucial phases of a computer-aided diagnosis system: (i) image enhancement through enhanced median filtering algorithms based on the range method, fuzzy relational method, and similarity coefficient, and (ii) wavelet decomposition using DB4, Symlet, RBIO, and extracting seven unique entropy features and eight statistical features from the segmented image. The extracted features were then normalized and provided for classification based on supervised and deep-learning algorithms. The proposed system is comprised of enhanced filtering algorithms, Normalized Otsu’s Segmentation, and wavelet-based entropy. Statistical feature extraction led to a classification accuracy of 93.6%, 0.71% higher than the spatial domain-based classification. With better classification accuracy, the proposed system will assist clinicians and dermatology specialists in identifying skin cancer early in its stages.

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