The present work describes the design, synthesis, and evaluation of the anticancer properties of pyrazolone ring appended triarylmethanes by the condensation of diarylmethanols with pyrazolone in presence of a catalytic amount of p-TSA catalyst. The use of an inexpensive catalyst and accessing the desired product in good yields within a short span are the merits associated with this protocol. Furthermore, the in-silico, as well as in-vitro analysis and molecular docking of the designed molecules, were performed followed by their anticancer activity evaluation against cancer cell lines like MCF7, MDA-MB-231, HeLa, and DU-145. Few of the synthesized molecules demonstrated significant anticancer activity and could provide a new direction in the development of anti-cancer molecules.

Chitosan hydrochloride as biopolymer‐based, renewable, and recyclable heterogeneous catalyst was used for efficient one‐pot synthesis of perimidine derivatives. This newly developed greener methodology provides a very simple and greener route for the synthesis of perimidines in short time with excellent yield.

No abstract