Field trials were carried out to investigate the impact of “AVIGEN DUCK” immunomodulator on the IFN-γ concentration, IL-2, IL-6, lysozyme, and betalysine activity in the blood serum in White Pekin ducks’ parents. The IFN-γ, IL-2, and IL-6 were analyzed by immunoenzyme methods, while the lysozyme and beta-lysine activities were determined using conventional techniques. The measured values among experimental birds for most parameters were significantly higher than those in controls during the observed period. An exception to this trend were the concentrations of lysozyme and beta-lysine, in which an inverse relationship was noticed. During the experiments, the challenged flocks were bred without the use of antibiotics. Based on collected data we consider the immunomodulator “AVIGEN DUCK” a successful alternative tool in the fight against microbial resistance associated with the use of antibiotics in poultry farming, as well as a means of enhancing the natural immunity in aquatic birds.
The nonspecific immune response plays an important role in organism's defense against a variety of pathogens. Two major factors in this process are blood serum lysozyme and alternative pathway of complement activation (APCA). Over the past few decades, the application of various substances, targeting improved levels of natural immunity have become part of the mainstream trends in livestock rearing programs. The current study examined the influence of the polybacterial immunomodulator AVIGEN on the performance of the aforementioned immune factors among broiler chicken hybrids. The experimental group demonstrated better overall performance for both parameters of interest. APCA activity for the treated group (549.10±19.69 CH50) was significantly higher compared to the result obtained for the controls (377.40±9.58 CH50), (P<0.001). Results for the other parameter were even more indicative. The measured concentration of the serum lysozyme for the treated group was twice as high compared to the control birds -6.17±0.49 mg/L vs. 2.99±0.27 mg/L, respectively. Therefore, the introduction of the AVIGEN immunomodulator to animals' diet has strong potential to improve natural humoral immunity in poultry farming.
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