Prostatic ductal adenocarcinoma is aggressive, resembling endometrial carcinoma at histopathology. Prostatic ductal adenocarcinoma resembles Gleason score 6 tumour at T2-weighted MRI. MRI grading may underestimate ductal adenocarcinoma based on increased T2 signal.

Although DCa mimics Gleason score 3 + 3 = 6 tumor at T2W MRI; DCa resembles Gleason ≥7 CCa on mp-MRI.

PNL2 has high sensitivity and specificity for AML and PEComas as compared with non-MiTF renal tumours, and PNL2 appears to be a more useful biomarker for sclerosing and malignant PEComas. For cases that are limited in tissue quantity (i.e. core biopsies) and/or are morphologically suspicious for AML/PEComa, but negative or focally positive for HMB45 and melan-A, PNL2 may be a useful adjunctive biomarker.