Introduction: Based on the Health Profile of East Java Province it was noted that the maternal mortality rate is still high, with the highest cause of maternal death being preeclampsia/eclampsia which is 28.92%, and hemorrhage by 26.28%. Mothers with anemia have a higher risk of postpartum hemorrhage. This is caused by the lack of oxygen and nutrients in the uterine organs, resulting in a decrease in myometrium muscle contraction that causes hemorrhage. Objective: To determine the relationship between anemia in pregnancy and postpartum hemorrhage in Jombang Regional Hospital 2016-2019. Method: Researchers use analytic research with a case-control approach. The study population of women who experienced hemorrhage at Jombang Regional Hospital in 2016-2019 (as a case group population). And women who did not experience hemorrhage at Jombang Regional Hospital in 2016-2019 (as a control group population). The sample of each study was 36 respondents for the case and control groups with a non-probability sampling technique consecutive sampling, and a matching process was carried out. Results: The significance value in the Mann Whitney test was 0.000 (p<0.05), which means that H0 was rejected, there was a significant relationship between anemia in pregnancy and postpartum hemorrhage in Jombang Regional Hospital. As well as the strength of the relationship between anemia and postpartum hemorrhage which was calculated using the Contingency Coefficient test. shows a figure of 0.582, which shows a positive correlation with sufficient strength correlation. Conclusion: Based on the results of research that has been done shows that there is a relationship between anemia in pregnancy with postpartum hemorrhage in Jombang Regional Hospital 2016-2019.

Background Mesh-augmented surgery with polypropylene meshes (PPMs) is often used in urogynecology and pelvic reconstructive surgery. However, the various complications that arise from its integration process have resulted in a decrease in the number of mesh-augmented surgeries performed worldwide. An approach to improving mesh-tissue integration is coating PPMs with anti-inflammatory and wound-healing molecules, such as platelet-rich plasma (PRP), which is a component of biotechnologies that are capable of accelerating wound healing. Estrogen is also known to have a beneficial effect on wound remodeling; therefore, a hypoestrogenic status may have negative implications for wound healing. The mechanism of how PRP plays a role in wound remodeling, especially among individuals in a hypoestrogenic state, has not been fully described until now. Objective Our aim is to investigate the impact of applying PRP to PPMs in hypoestrogenic rabbit models. Methods Our study will be a randomized controlled trial involving hypoestrogenic rabbit models. Samples were categorized into either the PRP group or the PPM group (1:1 ratio), with a minimum sample size of 16 in each arm, via simple random sampling. All samples were put into a hypoestrogenic state via bilateral oophorectomy. After confirming a decrease in estradiol level, the meshes were implanted in the vesicovaginal space. The samples were euthanized on the 14th, 28th, or 90th day of the surgery. The mesh-tissue integration process will be analyzed based on inflammatory parameters (inflammatory infiltrate, interleukin-17, and interleukin-1B expression); angiogenesis (CD31 expression); and collagen deposition, which will be assessed by using Masson trichrome staining. Results Our study is in the protocol development stage. A preliminary study regarding its feasibility, including the feasibility of the preparation of hypoestrogenic rabbit models, mesh implantation in the rabbits’ vesicovaginal spaces, the PRP and amnion scaffold, started in February 2022. The results of our study are expected to be available by the end of 2022. Conclusions Our randomized controlled trial is designed to provide high-quality evidence on the effect of applying a PRP-decellularized amnion scaffold to PPMs in the vesicovaginal spaces of hypoestrogenic rabbit models. International Registered Report Identifier (IRRID) PRR1-10.2196/37942

aglycone isoflavone derived from soybean can become an alternative nutrient or candidate for herbal product for pelvic organ prolapse treatment.

HIGHLIGHTS 1. E2 and FSH levels in menopausal women are thought to have relationship with stress urinary incontinensia (SUI).2. It was found that E2 and FSH levels had no significant relationship with SUI severity in menopausal women.   ABSTRACT Objectives: This study aimed to analyze the relationship between E2 and FSH levels in menopausal women with the severity of Stress Urinary Incontinence (SUI) at Ulin Hospital, Banjarmasin, Indonesia. Materials and Methods: This study used an analytic observational method with cross-sectional design in menopausal women diagnosed with Urinary Incontinence (UI) from October 2020 - March 2021. The independent variables were E2 and FSH levels. The dependent variable was the severity of SUI in menopausal women. The severity of SUI was determined by the Incontinence Severity Index (ISI) scoring. Data were analyzed by Spearman correlation. Results: The subjects who met the criteria were 25 women. The results showed the prevalence rate of SUI was 5.8% with E2 and FSH levels of mild SUI (14.25 pg/mL and 49.70 mIU/mL), moderate (7.91 pg/mL and 54.13 mIU/mL), and severe (9.14 pg/mL) and 70.97 mIU/mL). The number of severity levels of mild SUI was 44%, moderate SUI was 48%, and severe SUI was 8%. Most patients with SUI aged >60 years, multipara, normal body mass index (BMI), duration of menopause <10 years, menarche <15 years, Intrauterine Device (IUD) contraception, and delivered with spontaneous vaginal delivery. There was no significant relationship between E2 levels and the severity of SUI with a p-value of 0.084 and a correlation coefficient of -0.353. There was no significant relationship between FSH level and severity of SUI with a p-value of 0.367 and a correlation coefficient of 0.189. Conclusion: There was no significant relationship between E2 and FSH levels and the severity of SUI in menopausal women. It is necessary to do research on other factors that influence the high severity of SUI in menopausal women.