BACKGROUND: Indonesia with its tropical rainforest and its endemic flora, namely, Laportea decumana (Robx) Wedd. which is used as a traditional medicine. If we want to adopt it in complementary of nursing therapy as herbal medicine, it must be proven on an evidence-based. METHODS: The design in this study was a literature review article. Search for articles using relevant ones obtained from data based on Pubmed, Proquest, Ebsco, ScienceDirect, and Google Scholar in the span of the past 10 years (2011–2021) obtained 248 articles. RESULTS: There are seven articles that are relevant and discuss their content and use in the health. CONCLUSION: L. decumana is found in Indonesia as well as in Papua New Guinea. L. decumana (Robx) Wedd. contains alkaloids, glycosides, steroids/triterpenoids, flavonoids, tannins, and saponins which have proven their antioxidant, antibacterial, analgesic, and cytotoxic activity.

Background: Laportea decumana (robx.) wedd. is a traditional medicine used by Indonesian people, especially in eastern Indonesia, Maluku Ambon. But its utilization has not been based on evidence-based research, so it still needs to be developed to be used as complementary nursing therapy in the future. Aim: This study aims to determine the phytochemical content and antioxidant activity of Laportea decumana (robx.) wedd. from Ambon Maluku. Method: Extraction is done by the maceration method with 96% ethanol solvent. Phytochemical tests are performed with thin-layer chromatography (TLC) to look at flavonoids, tannins and triterpenoids, then alkaloids and saponins using tube tests. The antioxidant activity test was conducted using the 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) method. Results: Laportea decumana (robx.) wedd. phytochemical test positively contains alkaloids, flavonoids, tannins, triterpenoids and saponins. The antioxidant activity of Laportea Decumana (Robx) Wedd Ethanol Extract (LDrW-EE) 22.81 ppm, Laportea Decumana (Robx) Wedd n-Hexane Extract (LDrW-NHE) 44.89 ppm and vitamin C 6.03 ppm. Conclusion: LDrW-EE antioxidant activity is better when compared to LDrW-NHE but no better than vitamin C