Background: Indonesia has a high number of COVID-19 cases and mortalities relative to not only among the Asia Pacific region but the world. Children were thought to be less affected by the virus compared to adults. Most of the public data reported combined data between adults and children. The Indonesian Pediatric Society (IPS) was involved in the COVID-19 response, especially in the area of child health. One of IPS's activities is collecting data registries from each of their chapters to provide a better understanding of COVID-19 in children.Objective: The objective of this study was to share the data of suspected and confirmed COVID-19 cases in children from IPS's COVID-19 data registry.Method: This is a retrospective study from the IPS's COVID-19 registry data. We collected the data of COVID-19 in children during March to December 2020 from each of the IPS chapters. We analyzed the prevalence, case fatality rate (CFR), age groups, diagnosis, and comorbidities of the children diagnosed with COVID-19.Result: As of December 21, 2020, there were 35,506 suspected cases of children with COVID-19. In total, there were 522 deaths, with a case fatality ratio (CFR) of 1.4. There were 37,706 confirmed cases with 175 fatalities (CFR 0.46). The highest mortality in confirmed COVID-19 cases was from children ages 10–18 years (42 out of 159 cases: 26%). The most common comorbidity and diagnosis found were malignancy (17.3%) and respiratory failure (54.5%).Conclusion: The CFR of confirmed COVID-19 cases in children in Indonesia is high and should be a major public concern.
In the published article, the text in the first paragraph, Methods section showed an incomplete information on the intention of the original data collection and incomplete information on the information comparing the original data with Ministry of Health (MOH) COVID-19 data collection.
ABSTRAK.Bawang putih (Allium sativum) telah terbukti memiliki banyak efek positif untuk kesehatan, antara lain antibakteri, antivirus, antijamur dan juga antioksidan. Selain itu, bawang putih juga memiliki beragam efek positif untuk sistem kardiovaskular, antara lain menyebabkan penurunan tekanan darah, mencegah terjadinya aterosklerosis, dan juga bersifat antitrombotik. Salah satu obat antitrombotik yang umum digunakan oleh masyarakat adalah aspirin. Aspirin bekerja dengan cara menghambat pembentukan tromboksan A2. Komponen antitrombotik yang dimiliki bawang putih adalah allisin, yang bekerja dengan berbagai cara, salah satunya dengan cara menghambat jalur pembentukan tromboksan A2 dan ADP. Penelitian ini bertujuan untuk mengetahui efektivitas bawang putih mentah, rebus, dan goreng bila dibandingkan dengan aspirin. Desain dari peneltian ini adalah eksperimental laboratoris dengan 8 (delapan) kelompok yang terdiri dari kelompok kontrol negative (CMC 1%), kontrol positif (Aspirin), kelompok bawang putih mentah dosis tinggi, bawang putih mentah dosis rendah, bawang putih rebus dosis tinggi, bawang putih rebus dosis rendah, bawang putih goring dosis tinggi, dan bawang putih goreng dosis rendah. Setiap kelompok terdiri dari 5 (lima) mencit yang akan menerima perlakuan dalam 1 (satu) bulan. Pada hari ke 30, waktu perdarahan dari setiap mencit akan diukur dengan cara memotong ekor mencit. Hasil dari penelitian ini menunjukkan bahwa kelompok kontrol positif (aspirin) memiliki waktu perdarahan terpanjang, disusul dengan kelompok bawang putih mentah dosis tinggi. Di peringkat ketiga ada kelompok kontrol negative (CMC 1%) dan kelompok bawang putih mentah dosis rendah yang memiliki waktu perdarahan yang sama. Sementara itu, kelompok bawang putih rebus dan goreng, baik pada dosis tinggi maupun rendah, menunjukkan waktu perdarahan yang lebih panjang dibandingkan dengan kelompok kontrol negative (CMC 1%).Pemanjangan waktu perdarahan ini kemungkinan disebabkan karena allisin pada bawang putih yang bersifat termolabil dan terdegradasi dengan peningkatan suhu.
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