In Pseudomonas aeruginosa, quorum sensing (QS) plays a key role in biofilm formation and the regulation of other virulence factors which make the bacterium resistant to antibacterial action. During QS, LasR is critical for transcriptional activation and virulence gene regulation. In this study, 21 compounds identified in the anti‐quorum sensing and antibiofilm extracts of Dioon spinolosum were screened against LasR using molecular docking and molecular dynamics (MD) simulations. From molecular docking, 8 compounds had docking scores better than the natural autoinducer molecule, and were therefore subjected to molecular dynamics simulations. MD analysis revealed that the compounds bound strongly to LasR while exposing the binding pocket to bulk solvent. This potentially leads to protein aggregation and prevention of LasR dimerization. Hence, this study provides molecular basis for the anti‐quorum sensing and antibiofilm activities of compounds isolated from Dioon spinulosum and thus, can be considered for antibiotics development.

This paper empirically examines the extent of satisfaction experienced by customers and their switch intention within the Ghanaian banking industry, with special focus on Ghana Commercial bank. The study involved a cross-sectional survey of 200 respondents using structured questionnaire personally administered. All the questionnaires were retrieved and analysed using the Original Research ArticleStatistical Package for the Social Science (SPSS 16.0). The findings indicate that customers were not satisfied with the overall service of the bank but that has no significant effect on their switch intention. Quality, Price and Brand image each also has a positive relationship with customer overall satisfaction of service within the banking industry, the instance of Ghana Commercial Bank. Theoretically, it found a positive relationship between service satisfaction and switches intentions; and between quality, price and brand image and overall service satisfaction. Quality, price and brand image may be viewed as separate constructs of service satisfaction. Managers could influence Service Satisfaction through the three critical aspects of Service Satisfaction unique to the banking industry, but cannot influence switch intentions through service satisfaction level experienced. The paper contributes to the body of knowledge in the area of service satisfaction and switches intentions and as well constructs of service satisfaction and provides important theoretical and managerial implications for major players within the banking industry.