O herpesvírus que causa a varicela (catapora) persiste de forma latente no sistema nervoso, podendo se reativar e propagar através das raízes nervosas e se manifestar de forma tardia através de lesões cutâneas dolorosas, condição essa denominada herpes-zóster. O diagnóstico é primariamente clínico, devendo ser feito diagnóstico diferencial com impetigo, dermatite de contato, dermatite herpetiforme e, também, com o próprio herpes simples. Uma vez confirmado o diagnóstico, o tratamento deve ser instituído nas primeiras 72 horas após a erupção das lesões e tem como base a terapia antiviral. Dentre os antivirais, o valaciclovir e o fanciclovir têm eficácia superior quando comparados ao aciclovir. A complicação mais frequente do herpes-zóster é a neuralgia pós-herpética, usualmente manejada com antidepressivos tricíclicos, anticonvulsivantes, lidocaína tópica ou capsaicina. Recentemente foi introduzida no Brasil uma vacina de vírus atenuado para o herpes-zóster, composta pelo mesmo vírus da vacina contra varicela, porém em concentração maior. Entretanto, essa vacina ainda apresenta custo elevado e não está disponível no Sistema Único de Saúde.

Introdução: O Brasil possui taxa de cesariana de aproximadamente 50%, enquanto a Organização Mundial de Saúde considera taxas acima de 15% difíceis de serem justificadas do ponto de vista médico. Objetivo: Avaliar a prevalência, indicações e determinantes da cesariana em instituição do município de Vespasiano. Métodos: Estudo transversal de análise de dados dos prontuários de hospital de Vespasiano, cidade da região metropolitana de Belo Horizonte, no período de agosto de 2012 a outubro de 2013. Resultados: Foram avaliadas 82 parturientes utilizando as variáveis propostas e comparando os dados de mulheres que realizaram parto vaginal com as que realizaram cesariana. A prevalência das cesarianas foi 63,41% e suas principais indicações foram a desproporção céfalo-pélvica (42,31%), iterativa 1 (17,31%) e o pós-datismo (17,31%). A classificação de Robson foi adotada para avaliação da taxa de cesárea, sendo que o grupo 2 (nulíparas, feto único cefálico, termo, com parto induzido ou cesariana sem trabalho de parto) foi o maior contribuinte para essa taxa, correspondendo a 26,83% das cesarianas. Comparativamente ao parto vaginal, os determinantes para a cesariana foram a presença de cesarianas anteriores (p=0,04), ausência de trabalho de parto (p=0,000) e bolsa amniótica íntegra (p=0,002) à admissão. Conclusão: A prevalência de cesariana na instituição avaliada foi superior a quatro vezes o recomendado pela Organização Mundial de Saúde. Significativa proporção de cesarianas poderia ter sido evitada se as recomendações validadas pela literatura fossem aplicadas na condução do parto.

We performed a comprehensive analysis of angiosarcoma (AS) genomic biomarkers and their associations with the site of origin. We aimed to describe the genomic landscape of AS in a cohort of 143 cases of AS profiled by Caris Life Sciences. Data of Next Generation Sequencing (NGS) with a 592 gene panel was available for the entire cohort. Fifty-three cases had data of Whole Exome Sequencing (WES) which we used to study the microenvironment phenotype. Immuno-therapy (IO) response biomarkers: Tumor Mutation Burden (TMB), Microsatellite Instability (MSI) and PD-L1 status were included. IO-response markers were present in 36.4% of the cohort and in 65% of head and neck AS (H/N-AS) (p<0.0001). H/N-AS cases had predominantly muta-tions in TP53 (50.0%, p=0.0004), POT1 (40.5%, p<0.0001) and ARID1A (33.3%, p=0.5875). In breast AS, leading alterations were MYC amplification (63.3%, p<0.0001), HRAS (16.1%, p=0.0377), and PI3KCA (16.1%, p=0.2352). A microenvironment with a high immune signature, associated with better response to IO, was present in 13% of the cases. This signature was evenly distributed among different primary sites. We found that the molecular biology for AS varies significantly according to the primary site. Our findings can facilitate the design and optimiza-tion of therapeutic strategies for AS to overcome resistance to IO and targeted therapies.

e23508 Background: Bone sarcomas account for about 5% of cancers in adolescents and young adults (AYA). Outcomes in this population are consistently inferior than children. It is poorly understood whether this is related to the tumor biology or the therapeutic approach. In addition, regimens used in AYAs are heterogeneous due to poor tolerance of pediatric regimens and lack of clinical trials specific to this population. We sought to study the therapeutic regimes and outcomes of AYA bone sarcoma patients (pts) to understand the optimal therapeutic approach better. Methods: From our institutional database, we extracted data of pts with the diagnosis of “osteosarcoma” (OS) and “Ewing sarcoma” (ES) in the AYA (15-39 yo) population from 2011-21. We included only pts with efficacy documented to different regimens. Descriptive statistics were used for patient demographics, presentation, regimens, and outcomes (Table). Objective response rate (ORR) was defined as the number of patients achieving a partial or complete response. Relapse rate (RR) was calculated for the pts that progressed after undergoing definitive curative intent treatment. Survival comparison between groups was made using the Kaplan Meier method and Log Rank Test. We used Fisher's exact test to compare differences in ORR between treatment groups. Results: We identified 30 ES and 44 OS pts. For both ES and OS, Kaplan Meier survival analysis showed no difference in presentation adjusted overall survival between treatment groups; ( x2 .351, p .55) for ES and ( x2 1.94 p .378) for OS. Importantly, in OS, ORR difference between Adria/IVCis and Adria/IACis was statistically significant ( p .0188). Conclusions: Our study shows the heterogeneity in first-line treatment strategies for AYA pts with bone sarcomas. For ES, response rates for VAC/IE and VAI were similar. In the OS cohort, we found ORR for Adria/IACis was 81% which was statistically different to pts receiving Adria/IVCis (ORR 30%). However, we saw relapses in 43% of pts treated with Adria/IACis. This indicates that the intra-arterial approach could be helpful for limb preservation but suggests the need for intense adjuvant chemotherapy to prevent relapses. There were no statistically significant differences in the survival outcomes of AYA bone sarcoma pts treated with pediatric versus adult regimens.[Table: see text]